Registration Dossier
Registration Dossier
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EC number: 203-643-7 | CAS number: 109-06-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Pyridine and its methyl derivatives are rapidly absorbed and distributed to the body water component. They are metabolized in the liver and eliminated in the urine. There is a low risk of bioaccumulation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
A category of pyridine and alkyl pyridine derivatives is comprised of pyridine (CAS 110 -86 -1), 2-methylpyridine (CAS 109 -06 -8), 3-methylpyridine (CAS 108 -99 -6) and 4-methylpyridine (CAS 108 -89 -4). The foundation of the category is a common functional group (the pyridine unsaturated ring structure) and similar physico-chemical properties, environmental fate and toxicity, and mammalian toxicity. Similar toxicological properties derive from physico-chemical parameters and common pathways of metabolism and elimination among all members of the category. Three of four members of this category have harmonized classification and labelling. Read-across for non-harmonized endpoints is adequate for risk assessment purposes.
Pyridine and its methyl derivatives are absorbed during inhalation, oral and dermal exposures. They are distributed into the body water compartment as evidenced by the finding of the highest levels in the kidney and being eliminated primarily in the urine. Pyridine and its derivatives are metabolised by CYP enzymes in the liver, with primary metabolites being pyridine-N-oxide, 2-pyridone, 4-pyridone, 3-hydroxypyridine, and N-methyl pyridinium ion. These substances have a low risk of bioaccumulating in body fat or milk.
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