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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: literature review
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Anecdotal reports of effects of exposure of methyl pyridines.

Data source

Reference
Reference Type:
review article or handbook
Title:
2-Methylpyridine: Human toxicity excerpts
Author:
Anonymous
Year:
2010
Bibliographic source:
Hazardous Substances Data Base(HSDB), ToxNet, http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~rYtOpf:1

Materials and methods

Study type:
other: case reports
Endpoint addressed:
other: acute and chronic exposure by workplace exposure (inhalation and dermal)
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
case reports of exposures
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpyridine
EC Number:
203-643-7
EC Name:
2-methylpyridine
Cas Number:
109-06-8
Molecular formula:
C6H7N
IUPAC Name:
2-methylpyridine

Method

Type of population:
occupational
Ethical approval:
not applicable
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified

Results and discussion

Any other information on results incl. tables

2-METHYLPYRIDINE
CASRN: 109 -06 -8

For other data, click on the Table of Contents


Human Toxicity Excerpts:
CLINICAL SIGNS OF INTOXICATION CAUSED BY ALKYL DERIVATIVES OF PYRIDINE INCLUDE WEIGHT LOSS, DIARRHEA, WEAKNESS, ATAXIA, AND UNCONSCIOUSNESS. /ALKYL DERIVATIVES OF PYRIDINE/
[International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1811] **PEER REVIEWED**

Exposures to the picolines may give rise to flushing of the face, skin rash, an incr in heart & respiration rates, headache, giddiness, nausea & vomiting. /Picolines/
[International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1577] **PEER REVIEWED**

... IT HAS BEEN ALLEGED THAT THE WORKMEN EXPOSED TOPICOLINEVAPORS MAY DEVELOP DIPLOPIA AS A RESULT OF DISTURBANCE OF THE EYE MUSCLES. /PICOLINES/
[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 737] **PEER REVIEWED**

MODERATELY TOXIC & IRRITANT.
[Hawley, G.G. The Condensed Chemical Dictionary. 10th ed. New York: Van Nostrand Reinhold Co., 1981., p. 815] **PEER REVIEWED**

2-Methylpyridine causes local irritation on contact with the skin, mucous membranes & cornea.Clinical signs of intoxication caused by the methylpyridines include weight loss, diarrhea, weakness, ataxia & unconsciousness as well as narcosis headache, methylpyridine results in anemia & ocular & facial paralysis in addition to the previously mentioned symptoms.
[Snyder, R. (ed.). Ethyl Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 222] **PEER REVIEWED**

Applicant's summary and conclusion

Conclusions:
2-Methylpyridine causes local irritation on contact with the skin, mucous membranes & cornea. Clinical signs of intoxication caused by alkyl deriv of pyridine include weight loss, diarrhea, weakness, ataxia and unconsciousness.