Registration Dossier
Registration Dossier
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EC number: 237-525-1 | CAS number: 13826-35-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from QSAR Toolbox version 3.3
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: The prediction is done using QSAR Toolbox version 3.3
- Principles of method if other than guideline:
- The prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Type of study:
- not specified
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- no data
- Vehicle:
- no data
- Concentration / amount:
- no data
- Vehicle:
- no data
- Concentration / amount:
- no data
- No. of animals per dose:
- no data
- Details on study design:
- no data
- Challenge controls:
- no data
- Positive control substance(s):
- not specified
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- not sensitising
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: not sensitising.
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The skin sensitisation effect of 3-Phenoxybenzyl alcohol in guinea pig was estimated using QSAR Toolboox version 3.3
The test substance 3-Phenoxybenzyl alcohol was estimated to be non-sensitising to skin of guinea pig - Executive summary:
The skin sensitisation effect of 3-Phenoxybenzyl alcoholin guinea pig was estimated using QSAR Toolboox version 3.3
The test substance 3-Phenoxybenzyl alcoholwas estimated to be non-sensitising to skin of guinea pig. Considering the CLP criteria for classification of substances, it is concluded that 3-Phenoxybenzyl alcoholis likely to be non-classified as a skin sensitiser.
Reference
The prediction was based on dataset comprised from the following descriptors: "Skin Sensitisation"
Estimation method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((((((("a" or "b" or "c" or "d" or "e" ) and ("f" and ( not "g") ) ) and ("h" and ( not "i") ) ) and ("j" and ( not "k") ) ) and ("l" and ( not "m") ) ) and ("n" and ( not "o") ) ) and ("p" and "q" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Benzyl Alcohols by Aquatic toxicity classification by ECOSAR
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Alcohol AND Aryl AND Benzyl AND Ether by Organic Functional groups
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Alcohol AND Aryl AND Benzyl AND Ether AND Overlapping groups by Organic Functional groups (nested)
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Oxygen, two aromatic attach [-O-] AND Aromatic Carbon [C] AND Hydroxy, aliphatic attach [-OH] AND Olefinic carbon [=CH- or =C<] AND Oxygen, two olefinic attach [-O-] by Organic functional groups (US EPA)
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Alcohol AND Aromatic compound AND Diarylether AND Ether AND Hydroxy compound AND Primary alcohol by Organic functional groups, Norbert Haider (checkmol)
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as Not possible to classify according to these rules by DPRA Cysteine peptide depletion
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as High reactive OR High reactive >> Activated haloarenes by DPRA Cysteine peptide depletion
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Inclusion rules not met by Skin irritation/corrosion Inclusion rules by BfR
Domain logical expression index: "i"
Referential boundary: The target chemical should be classified as Ketones by Skin irritation/corrosion Inclusion rules by BfR
Domain logical expression index: "j"
Referential boundary: The target chemical should be classified as Not categorized by Repeated dose (HESS)
Domain logical expression index: "k"
Referential boundary: The target chemical should be classified as Allyl esters (Hepatotoxicity) Rank A OR Thiocarbamates/Sulfides (Hepatotoxicity) No rank by Repeated dose (HESS)
Domain logical expression index: "l"
Referential boundary: The target chemical should be classified as Non-Metals by Groups of elements
Domain logical expression index: "m"
Referential boundary: The target chemical should be classified as Halogens by Groups of elements
Domain logical expression index: "n"
Referential boundary: The target chemical should be classified as No Data by Ultimate biodeg
Domain logical expression index: "o"
Referential boundary: The target chemical should be classified as 1 to 10 days by Ultimate biodeg
Domain logical expression index: "p"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.676
Domain logical expression index: "q"
Parametric boundary:The target chemical should have a value of log Kow which is <= 4.68
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitisation effect of3-Phenoxybenzyl alcoholin guinea pig was estimated using QSAR Toolboox version 3.3
The test substance3-Phenoxybenzyl alcoholwas estimated to be non-sensitising to skin of guinea pig. Considering the CLP criteria for classification of substances, it is concluded that3-Phenoxybenzyl alcoholis likely to be non-classified as a skin sensitiser.
Migrated from Short description of key information:
The skin sensitisation effect of 3-Phenoxybenzyl alcohol in guinea pig was estimated using QSAR Toolboox version 3.3
The test substance 3-Phenoxybenzyl alcohol was estimated to be non-sensitising to skin of guinea pig
Justification for selection of skin sensitisation endpoint:
Data is from OECD recommended QSAR model.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
