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EC number: 237-525-1 | CAS number: 13826-35-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In an experiment to study the metabolism in Rats of 3-Phenoxybenzyl Alcohol, male SD rats were given a single oral dose of the 14C-preparations of 3-Phenoxybenzyl Alcohol in 10% Tween 80 (1 ml) at a rate of 9 µmol kg-1. The administered 3-Phenoxybenzyl Alcohol was absorbed in the GI tract and metabolized to 3-phenoxybenzoic acid and 3-(4-sulphonyloxyphenoxy) benzoic acid. At the end of 7 days, a total of 99.4 (+ 0.6) of the % of the dose administered was excreted out of the body of rats in urine and feaces.
Thus, it is concluded that the bioaccumulation potential of the chemical 3-Phenoxybenzyl Alcohol is expected to be low.
Key value for chemical safety assessment
Additional information
Specific-pathogen free (SPF) and germ-free rats were each given a single oral dose of the14C-preparations of3-Phenoxybenzyl alcoholin 10% Tween 80 (1 ml) at a rate of 9 µmol kg-1. The SPF rats were individually housed in all-glass metabolism cages. The urine and faeces were collected separately for 1 day (germ-free rats), and for up to 7 days (SPF rats). The administered3-Phenoxybenzyl Alcohol was absorbed in the GI tract and metabolized to3-phenoxybenzoic acidand 3-(4-sulphonyloxyphenoxy)benzoic acid. The major metabolites were3-phenoxybenzoic acidand 3-(4-sulphonyloxyphenoxy) benzoic acid in the liver, and3-phenoxybenzoic acidin the blood.
At the end of 7 days, a total of 99.4(+0.6)of the % of the dose administered was excreted out of the body of rats in urine and feaces. Thus, it is concluded that the bioaccumulation potential of the chemical3-Phenoxybenzyl alcohol is expected to be low.
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