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EC number: 237-525-1 | CAS number: 13826-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from online Chemical Repository Database
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- To observed acute inhalation toxicity given Inhalation exposure of rats for 1 hour to an aerosol and vapor atmosphere of 3 Phenoxybenzyl Alcohol at a concentration of 2.0 mg/l.
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 3-phenoxybenzylic alcohol
- EC Number:
- 237-525-1
- EC Name:
- 3-phenoxybenzylic alcohol
- Cas Number:
- 13826-35-2
- Molecular formula:
- C13H12O2
- IUPAC Name:
- (3-phenoxyphenyl)methanol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 3-Phenoxybenzyl alcohol
- Molecular formula (if other than submission substance): C13H12O2
- Molecular weight (if other than submission substance): 200.23318 g/mol
- Smiles notation (if other than submission substance): C1=CC=C(C=C1) OC2=CC=CC (=C2) CO
- InChl (if other than submission substance): InChI=1S/C13H12O2/c14-10-11-5-4-8-13(9-11)15-12-6-2-1-3-7-12/h1-9, 14H, 10H2
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: the Ethyl Corporation, Ferndale,Michigan
- Age at study initiation: No data available
- Weight at study initiation:
Male rats :200 to 254 grams
Females rats: 200 to 220 grams
- Fasting period before study: No data available
- Housing: The rats were housed individually in wire-mesh cages and were kept throughout the pre- and post exposure periods in a temperature and humidity controlled room in accordance with standards outlined in the "Guide For the Care and Use of Laboratory Animals; DREW No. (N.LH. 74-23) 1974".
- Diet (e.g. ad libitum): Purina Laboratory Chow(ad libitum)
- Water (e.g. ad libitum): Water ( ad libitum)
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no temperature mention , only temperature control room given
- Humidity (%):no humidity mention , only humidity control room given
- Air changes (per hr):Not data available
- Photoperiod (hrs dark / hrs light): Not data available
IN-LIFE DATES: From: To: Not data available
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Details on inhalation exposure:
- No data available
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 2 mg/l
- No. of animals per sex per dose:
- 5 male/ 5 female
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 48 hours
- Frequency of observations and weighing:
Frequency of observations: immediately following the 1 hour exposure period and twice daily after for 48 hours.
Frequency of weighing: Individual body weights were recorded prior to the 1 hour exposure and at 24 and 48 hours in order to detect any latent effects following the exposure.
- Necropsy of survivors performed: No necropsy was conducted because all of the rats survived the exposure and observation period.
- Other examinations performed: clinical signs, body weight
- other: The vapors and aerosols of the compound were generated by metering the liquid at the rate of 0.0494 ml/min with a Harvard® Infusion Pump into a positive pressure atomizer located near the chamber air inlet at the top of the exposure chamber. The "metered" concentration of the compound (2.0 mg/I) in the chamber atmosphere was calculated from the ratio of the rate of liquid dissemination (55.3 mg/min*) to the rate of total chamber airflow (27 l/min). The total chamber airflow represents the volume of air ejected from the atomizer plus the volume of make-up air. - Statistics:
- No data available
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 2 other: mg/l
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- None of the rats died in the experiment
- Clinical signs:
- other: The immediate response of the rats to the experimental atmosphere was an increase of activity in preening. After several minutes of exposure, this activity decreased. The rats appeared normal during the experimental period.
- Body weight:
- Details given in table below
- Gross pathology:
- No necropsy was conducted because all of the rats survived the exposure and observation period and were sacrificed and discarded.
Any other information on results incl. tables
Body weight gain appeared normal during the 48 hour observation period
Individual Body Weights, Grams |
||||
Group, Rat No. |
Sex |
Pre-exposure |
Post-exposure (Days) |
|
2.0 mg/l |
|
|
|
|
16770 |
M |
205 |
214 |
228 |
16771 |
M |
254 |
260 |
270 |
16772 |
M |
200 |
208 |
222 |
16773 |
M |
203 |
211 |
212 |
16774 |
M |
225 |
244 |
252 |
16775 |
F |
220 |
226 |
232 |
16776 |
F |
210 |
212 |
212 |
16777 |
F |
208 |
215 |
220 |
16778 |
F |
200 |
208 |
214 |
16779 |
F |
218 |
232 |
233 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LC0 value for the Charles River CD rat for 3-Phenoxybenzylalcohol (CAS No :13826-35-2) was found to be > 2 mg/l.
- Executive summary:
Acute inhalation study was performed on Charles River CD rats at 2 mg/l concentration. 5 male of weight from 200 to 254 grams and 5 female from 200 to 220 grams were used. The rats were housed individually in wire-mesh cages and were kept throughout the pre- and post-exposure periods in a temperature and humidity controlled room in accordance with standards outlined in the "Guide For the Care and Use of Laboratory Animals; DREW No. (N.LH. 74-23) 1974".
During exposure, the rats were caged individually in compartmented,Wire-mesh exposure cages. The cages were placed in a 160- liter cubical. Stainless steel and glass chamber. Constant chamber airflow was maintained by means of a rotary centrifugal air pump located at the exhaust side of the chamber. The chamber exhaust was filtered with an activated charcoal filter and a Cambridge Absolute filter before being discharged outside of the laboratory.
Observations for pharmacotoxic signs and mortality were made during and immediately following the 1 hour exposure period and twice daily thereafter for 48 hours.
None of the rats died in the experiment. No necropsy was conducted because all of the rats survived the exposure and observation period and were sacrificed and discarded.
Therefore, the LC0 value of 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) for Charles River CD rat was found to be >than 2 mg/l.
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