Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-831-0 | CAS number: 75-01-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h LC50 is 210 mg/l in the fresh water species Brachydanio rerio tested according OECD 203 (Groeneveld, 1993)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 210 mg/L
Additional information
A GLP-compliant OECD 203 guideline test was available and the 96-h LC50 value of vinyl chloride in Brachydanio rerio is 210 mg/l (Groeneveld, 1993). This value is used in the assessment, because the other two experimental studies that are available are older non-GLP studies with higher LC50 values (Industrial Bio-Test laboratories, Inc., 1971). Furthermore, calculated effect concentrations using ECOSAR are available for freshwater fish (U.S. EPA, 2000). The calculation of 115 mg/l is reliable, validated and falls within the applicability domain of the QSAR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
