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EC number: 229-764-5
CAS number: 6712-98-7
In the absence of specific data on the ADME of DEIPA, it’s physicochemical properties and relevant toxicity data (where available) were assessed for insights into likely ADME characteristics. DEIPA has a MW >100 and <500 and a log Pow >-1 and < 4, characteristics considered favourable for oral and dermal absorption. Signs of systemic toxicity observed following repeated oral administration in rats confirm that absorption can occur via this route. Due to DEIPA’s low volatility, inhalation of DEIPA vapours is not expected. However, ready absorption would be expected following inhalation of DEIPA aerosols. Wide tissue distribution of absorbed DEIPA could occur (due to its low MW). However, metabolism (probably involving oxidation of the two ethanol groups), excretion, a low MW and low Log Pow mean that bioaccumulation is unlikely. Urinary excretion is the most likely elimination pathway of absorbed DEIPA.
toxicokinetics based on the physicochemical properties of DEIPA, based
Miscible in all proportions
coefficient Log Pow: -1.0
61.2 mN/m at 20.3 °C
weight (MW) of the substance (163) and the Log Pow (-1.0) (Butler, 2012)
favour absorption from the gastro-intestinal tract following ingestion
(ECHA, 2012a). DEIPA is miscible with water in all proportions i.e.
soluble without limit (Butler, 2012) and thus will readily dissolve in
the gastrointestinal fluid (ECHA, 2012a). As the MW is below 200, it has
the potential to pass through aqueous pores or be carried through the
epithelial barrier by the bulk passage of water (ECHA, 2012a). Signs of
systemic toxicity observed in a repeated dose (28-day) oral gavage study
in rats (Stebbins and Zablotny, 1999) support the expectation that DEIPA
is absorbed orally. Therefore, a value of 100% oral absorption is
According to an
expert report, and based on a low estimated vapour pressure of 7 x10-7
kPa, inhalation of DEIPA vapours is not expected (NICNAS, 2009). A
recent guideline study established a comparable vapour pressure of 8.4 x
10-6 kPa for DEIPA (Atwal, 2012a); both values are below the
0.5 kPa threshold considered by ECHA (2012b) to display low volatility.
Considering the low vapour pressure and high boiling point (325°C), the
opportunity for exposure by inhalation is likely to be low.
absorption would be expected if inhalation of a DEIPA aerosol occurred. Since
DEIPA is miscible, it will readily diffuse into the mucous lining the
respiratory tract and the low Log Pow value favours absorption directly
across the respiratory tract epithelium by passive diffusion. Evidence
of absorption following oral exposure (signs of systemic toxicity) also
suggest that the substance will be absorbed following inhalation
exposure. A default value of 100% inhalation absorption is usually
applied in these circumstances (ECHA, 2012a).
The MW and Log
Pow are within ranges that favour dermal absorption. ECHA recommends a
default value of 100% skin absorption for such substances (MW below 500
and Log Pow between -1 and 4) (ECHA, 2012a). The liquid state and
miscibility of DEIPA are thought to assist penetration into the stratum
corneum and subsequently the epidermis, also favouring absorption.
No test data are
available regarding the distribution and metabolism of DEIPA. As a small
molecule, a wide tissue distribution is possible (ECHA, 2012a) but the
structure suggests that DEIPA will either be metabolised by oxidation of
the two ethanol groups to carboxylic acids, with subsequent conjugate
formation (e. g. glucuronidation or sulfation) or be directly
conjugated, in phase-II reactions.
The low MW and
probable ready oxidation/conjugation are indicative of ready excretion,
presumably via the urine. Based on that and on the low Log Pow,
bioaccumulation is not expected. Biliary excretion tends to be limited
to compounds of higher molecular weights (around 300 in the rat, approx.
>500 in humans) (ECHA, 2012a; OECD, 2011) and is likely not a
significant excretion route for DEIPA.
(2012a). European Chemicals Agency. Guidance on information requirements
and chemical safety assessment. Chapter R.7c: Endpoint specific
guidance. November 2012 (version 1.1).
(2011). Manual for the assessment of chemicals. Chapter 4. Initial
assessment of data. Available at:http://www.oecd.org/env/ehs/risk-assessment/49188998.pdf.
(2009). Australian National Industrial Chemicals Notification and
Assessment Scheme. Full Public Report. DEIPA. File No: STD/1344.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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