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EC number: 229-764-5
CAS number: 6712-98-7
In a GLP study, conducted according to OECD
guideline 471, DEIPA was assessed for mutagenicity in a bacterial
reverse mutation assay.
Two independent studies using the
preincubation method were performed using Salmonella typhimurium strains
TA98, TA100, TA1535, TA1537 and Escherichia coli strain WP2uvrA in the
presence and absence of a rat liver metabolic activation (S9 mix).
Concentrations of 100, 333, 1000, 3330, and 5000 µg/plate of DEIPA were
tested, along with concurrent positive and vehicle controls, all plated
in triplicate.The positive control substances all showed mutagenic
activity, demonstrating that the test was valid.
Following incubation of the test material,
tester strain and S9 mix (or phosphate buffer), the number of revertant
colonies per plate was counted. Cytotoxicity was evaluated based on the
condition of the bacterial background lawn. No precipitation of
the test article was obseved at any dose level.
the conditions of this study, DEIPA did not cause a positive increase in
the number of revertant colonies per plate and no cytotoxicity was
evident, with any of the tester strains, at any concentration, either in
the presence or absence S9.
DEIPA showed no convincing evidence of
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