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Short-term toxicity to aquatic invertebrates

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Description of key information

In a GLP study, conducted according to OECD guideline 202, the EC50 and LC50 values for DEIPA with Daphnia magna at 48-hr can be determined as greater than 100 mg/L in a freshwater static limit test. The 48-hr NOEC was considered to be 100 mg/L since no mortalities or sublethal effects were observed at this level (Marino et al. 1999b).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
100 mg/L

Additional information

In a GLP study, conducted according to OECD guideline 202, the acute toxicity of DEIPA to Daphnia magna Straus was evaluated in a 48-hr freshwater static limit test. The test was performed at a target concentration of 100 mg/L (mean measured concentration of 93.1 mg/L) and 0 mg/L (daphnid water control) with 10 daphnids per dose level and 3 replicates per concentration. To determine the DEIPA concentration, the test solutions were analysed on study days 0 and 2 by gas chromatography with mass selective detection following derivatisation with pentafluorobenzoyl chloride. The oxygen level, temperature and pH were also monitored on days 0 and 2. The daphnia were observed 6, 24 and 48 hours after exposure for mortality and immobility. The NOEC was considered to be 100 mg/L since no mortalities or sublethal effects were observed in the water control or DEIPA exposed Daphnids during the 48-hr study duration. The 48-hr EC50 (concentration that effects 50% of the test population), LC50 (concentration that is lethal to 50% of the test population) can be determined as greater than 100 mg/L (Marino et al. 1999b).

In summarising this study, NICNAS (2009) concluded that DEIPA was not acutely harmful to daphnia.

Using the ECOSAR (v1.0) programme [class aliphatic amines] in EPISuite (v4.10) a 48-hr EC50 of 346 mg/L (ppm) for freshwater daphnia and a 96-hr EC50 of 362 mg/L for saltwater mysid shrimp has been predicted (US EPA, 2011).

References

NICNAS (2009). Australian National Industrial Chemicals Notification and Assessment Scheme. Full Public Report. DEIPA. File No: STD/1344. December 2009.http://www.nicnas.gov.au/publications/CAR/new/Std/StdFULLR/std1000FR/std1344FR.pdf 

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