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Short-term toxicity to fish

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Description of key information

In a GLP study, conducted according to OECD guideline 203, 96-hr EC50 and LC50 values for DEIPA of greater than 100 mg/L in a freshwater static limit test with rainbow trout (Oncorhynchus mykiss) were determined. The NOEC was considered to be 100 mg/L since no mortalities or sublethal effects were observed at this level (Marino et al. 1999a).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
100 mg/L

Additional information

In a GLP study (reliability 1), conducted according to OECD guideline 203, the acute toxicity of DEIPA to rainbow trout (Oncorhynchus mykiss) was evaluated in a 96-hr freshwater static limit test. The test was performed at a target concentration of 100 mg/L and 0 mg/L (water control) with 10 fish per dose level and 3 replicates per concentration. The fish were observed after 4 hr of exposure and every 24 hr thereafter for mortality and sublethal effects. The no-observed-effect concentration (NOEC) was considered to be 100 mg/L since no mortalities or sublethal effects were observed at this level over the 96-hr study duration. The 96-hr EC50 (concentration that effects 50% of the test population) and LC50 (concentration that is lethal to 50% of the test population) can be determined as greater than 100 mg/L (Marino et al. 1999a).

In summarising this study, NICNAS (2009) concluded that DEIPA was not acutely harmful to fish.

Using the ECOSAR (v1.0) programme [class aliphatic amines] in EPISuite a 96-hr LC50 of 7926 and 8160 mg/L (ppm) has been predicted for fresh- and salt-water fish, respectively (US EPA, 2011). DEIPA is a readily-biodegradable miscible liquid and no adverse effects were seen in a reliable short-term toxicity test with freshwater invertebrates at up to 100 mg/L. Therefore, long-term toxicity testing is not considered a high priority for further work.

References

NICNAS (2009). Australian National Industrial Chemicals Notification and Assessment Scheme. Full Public Report. DEIPA. File No: STD/1344. December 2009.http://www.nicnas.gov.au/publications/CAR/new/Std/StdFULLR/std1000FR/std1344FR.pdf 

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