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EC number: 215-149-9
CAS number: 1306-25-8
The objectives of this 14-day pilot study (dose range finding
study) was to examine whether the feeding of Cadmium telluride up
to 100 mg/kg bw (1500 ppm) for14 days was
tolerated by Wistar Han rats and to provide data for the
selection of the dose levels for a subsequent sub-chronic (90-day) oral
toxicity study with Cadmium telluride. In addition, it was evaluated
what the cadmium and tellurium concentrations in the liver and kidney
were compared to when Cadmium chloride was being dosed.
The study design was as follows:
Test Item Id.
Number of Animals
The following parameters and endpoints were evaluated in this
study: clinical signs, body weights, food consumption, cadmium and
tellurium concentrations in liver, kidney, urine and feces, gross
necropsy findings and kidney and liver weights.
For the cadmium telluride groups and reference group (cadmium
chloride), the following was concluded:
No mortality occurred during the study period.
No treatment-related clinical signs were noted during daily
detailed clinical observations.
Body weights and body weight gain of treated animals remained in
the same range as controls over the study period.
Food consumption before or after correction for body weight was
similar to the control level over the study period.
Macroscopic observations at necropsy did not reveal any
alterations that were considered to have arisen as a result of treatment.
Organ weights and organ to body weight ratios of treated animals
were considered to be similar to those of control animals.
Based on the results of the tolerability study,administration of
Cadmium telluride in diet was well tolerated in rats at levels up to
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