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EC number: 215-149-9
CAS number: 1306-25-8
An exposure to the Cadmium telluride (CdTe) in the form of a dry
aerosol to Wistar rats for up to 28 consecutive days at concentration
levels of 0.003, 0.01, 0.03 and 0.09 mg/L was associated with following
-Exposure to the test atmosphere at 0.09 mg/L for six
hours/day, caused the loss of two
animals and early termination of the exposure due to ethical reasons on
Week 4.(Study Days 24 and 23, males and females,
respectively). Exposure resulted in severe tachypnea (increased
respiratory rate) and decreased activity, expressed body weight loss and
reduced food consumption. Changes in hematology and clinical chemistry
parameters reflected poor condition of the animals, however changes in
some of the parameters might be indicative for liver and kidney
impairment. An increase in lung weights (2-3 times versus control) was
associated with mild to moderatealveolar/interstitial
inflammation,mild to moderate
interstitial fibroplasia and degeneration/necrosis of the macrophages in
the lung associated lymph nodes. Weight of the thymus was markedly
-Exposure at 0.03 mg/L for six hours was associated
with slight/moderate tachypnea, moderate body weight gain suppression
and/or in females slight temporary body weight loss and minimal changes
in a few clinical chemistry parameters. An increase in lung weights (2-3
times versus control), correlated with minimal to mild
alveolar/interstitial/bronchiolar inflammation, minimal to mild
degeneration/necrosis of the macrophages in the lung-associated lymph
-Exposure at 0.01 mg/L for six hours resulted in
slight tachypnea, minimal body weight gain suppression in males and an
increase in lungs weight (2-2.7 times versus control), which correlated
with minimal alveolar/interstitial/bronchiolar inflammationand
minimal degeneration/necrosis of the macrophages in the lung-associated
-Exposure at 0.003 mg/L (achieved by exposure of 0.01 mg/L
for two hours) was associated with slight, transient tachypnea during
the last week of the exposure, increase in lungs weights (by about 1.5-2
times), which correlated with minimal alveolar/interstitial/bronchiolar
inflammation and minimal hyperplasia of the Type II pneumocytes .
In conclusion, under the conditions of this study, CdTe
administered to Han Wistar rats as dry aerosol by the inhalation route,
daily for 28 days at the lowest possible concentration of 0.01 mg/L for
2 hours was considered to have an adverse effect on the respiratory
tract. Therefore the no observed adverse effect-level (NOAEL) was not
found in this study.
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