Registration Dossier
Registration Dossier
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EC number: 201-163-2 | CAS number: 78-97-7
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standards with acceptable restrictions (non-GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
- Principles of method if other than guideline:
- Method: other: BASF-Test according to DIN 38 412
- GLP compliance:
- no
Test material
- Reference substance name:
- Lactonitrile
- EC Number:
- 201-163-2
- EC Name:
- Lactonitrile
- Cas Number:
- 78-97-7
- Molecular formula:
- C3H5NO
- IUPAC Name:
- 2-hydroxypropanenitrile
- Details on test material:
- Milchsaeurenitril (Lactonitrile)
Purity: 88%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Leuciscus idus
Study design
- Test type:
- static
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 0.46 mg/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.22 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.22 - 0.46 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 0.22 mg/L
Any other information on results incl. tables
- Sublethal observations / clinical signs:
- RS-Freetext:
LC50 after
1 hr: > 1 mg/L
4 hr: > 1 mg/L
24 hr: > 0.22 < 0.46 mg/L
48 hr: > 0.22 < 0.46 mg/L
72 hr: > 0.22 < 0.46 mg/L
96 hr: > 0.22 < 0.46 mg/L
Symptoms: apathy, narcotic-like state, tumbling (observed in the highest dose group)
Mortality
Treatment/ 1h / 4h / 24h / 48h / 72h / 96h
-----------------------------------------------------------
0.000mg/L/ 0/10/ 0/10/ 0/10/ 0/10/ 0/10/ 0/10
0.100mg/L/ 0/10/ 0/10/ 2/10/ 2/10/ 2/10/ 2/10
0.215mg/L/ 0/10/ 0/10/ 0/10/ 0/10/ 0/10/ 0/10
0.464mg/L/ 0/10/ 0/10/ 10/10/ 10/10/ 10/10/ 10/10
1.000mg/L/ 0/10/ 0/10/ 10/10/ 10/10/ 10/10/ 10/10
-----------------------------------------------------------
The death of two fishes of the 0.100 mg/L treatment was obviously not substance related and was therefore not considered for the results
Applicant's summary and conclusion
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