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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

skin irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July to December 2011
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: in-vitro study performed according to OECD guideline and under GLP conditions

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guideline
according to guideline
other: OECD 431
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
Absorbent N grade A
Absorbent N grade A
Details on test material:
- Name of test material (as cited in study report): Absorbent N grade A
- Substance type: UVCB
- Physical state: Brown liquid
- Stability under test conditions: months
- Storage condition of test material: room temperature, in the dark

Test animals


Results and discussion

Any other information on results incl. tables




Test Item

3 minutes

Test Item

60 minutes

Viability (Vitality) / Mean [%]





In accordance to the OECD Guideline 431 a test item is considered to be corrosive to skin

  • if the viability after 3 minutes exposure is less than 50 %. or
  • if the viability after 3 minutes exposure is greater than or equal to 50 % and the viability after 1 hour exposure is less than 15 %.

Thereafter the test item “Absorbent N Grade A” was considered to be non-corrosive to skin according to OECD Guideline 431. The positive controls proveadditionally the well functioning of the skin models.

Applicant's summary and conclusion

Interpretation of results:
other: non-corrosive
Criteria used for interpretation of results: EU
According to the definition of the OECD-Guideline 431 the test item was considered to be non-corrosive.
Executive summary:

The aim of this study was the detection of a corrosion potency of „Absorbent N Grade A“ tested on a Human Skin Model.

According to the definition of skin corrosion, inserts were incubated with the specimen for 3 min and 1 h. To avoid an evaporation during incubation all inserts were covered with a tin foil. After the indicated time the inserts were rinsed thoroughly with PBS. Finally, cell viability was measured by performing a standard MTT assay.

Viability was determined to be 94.9% after 3 min and 61.1% after 1h.

According to the definition of the OECD-Guideline 431 the test item is considered to be non-corrosive.