Registration Dossier
Registration Dossier
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EC number: 700-774-6 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July to December 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: in-vitro study performed according to OECD guideline and under GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 431
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Absorbent N grade A
- IUPAC Name:
- Absorbent N grade A
- Details on test material:
- - Name of test material (as cited in study report): Absorbent N grade A
- Substance type: UVCB
- Physical state: Brown liquid
- Stability under test conditions: months
- Storage condition of test material: room temperature, in the dark
Constituent 1
Test animals
- Species:
- human
Results and discussion
Any other information on results incl. tables
- if the viability after 3 minutes exposure is less than 50 %. or
- if the viability after 3 minutes exposure is greater than or equal to 50 % and the viability after 1 hour exposure is less than 15 %.
Viability
|
Test Item 3 minutes |
Test Item 60 minutes |
Viability (Vitality) / Mean [%] |
94.9 |
61.1 |
In accordance to the OECD Guideline 431 a test item is considered to be corrosive to skin
Thereafter the test item “Absorbent N Grade A” was considered to be non-corrosive to skin according to OECD Guideline 431. The positive controls proveadditionally the well functioning of the skin models.
Applicant's summary and conclusion
- Interpretation of results:
- other: non-corrosive
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- According to the definition of the OECD-Guideline 431 the test item was considered to be non-corrosive.
- Executive summary:
The aim of this study was the detection of a corrosion potency of „Absorbent N Grade A“ tested on a Human Skin Model.
According to the definition of skin corrosion, inserts were incubated with the specimen for 3 min and 1 h. To avoid an evaporation during incubation all inserts were covered with a tin foil. After the indicated time the inserts were rinsed thoroughly with PBS. Finally, cell viability was measured by performing a standard MTT assay.
Viability was determined to be 94.9% after 3 min and 61.1% after 1h.
According to the definition of the OECD-Guideline 431 the test item is considered to be non-corrosive.
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