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EC number: -
CAS number: -
The study was performed to assess the acute dermal irritation/corrosion of E Stage 3 intermediate in Japanese White rabbits. The method was designed to be in accordance with the guidelines for the testing of chemicals 'Acute Dermal Irritation/Corrosion' (404) published by the Ministry of Environmental Protection of People's Republic of China in the year 2013.
Three male rabbits were used for the study. A quantity of 0.5g of the test item was applied to the right side of back skin of each animal for an exposure period of 4 hours. The untreated skin on the left back area of the animal served as the control. Clinical signs were performed once daily throughout the study. The skin sites of each animal for signs of erythema/eschar and oedema were all recorded immediately, and 1, 24, 48 and 72 hours after patch removal. All local toxic effects on skin as well as systemic toxicity were also fully described and recorded. Dermal reactions (erythema/eschar and oedema of test sites were scored at approximately 24, 48 and 72 hours after patch removal. Mean scores of erythema/eschar or oedema at 24, 48 and 72 hours were calculated for tested skins after patch removal. Individual animal body weights were recorded on the day of dosing and on the completion of fiinal observations.
No abnormal signs or symptoms were observed in any animal throughout the course of the test. The scores of erythema/eschar and oedema for all animals at approximately 24, 48 and 72 hours were all 0 after patch removal. All animals showed expected gain in bodyweight during the study.
Based on the above results, E Stage 3 intermediate was considered to have no irritant effects on the skin of rabbits was classified as 'unclassified' according to GHS classification for eye irritation.
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