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EC number: -
CAS number: -
The study was designed to determine the potential for E Stage 3 Intermediate to elicit a skin sensitisation reaction. The method was designed to be meet the Guidelines for the testing of chemicals 'Skin sensitisation study' (406) published by the Ministry of Environmental Protection of People's Republic of China in the year 2013.
Thirty animals were used in the study, which included one control group (10 animals) and one treated group (20 animals). In the induction phase, for treated group on Day 0, Day 7 and Day 14, 0.3g of the test item was applied to the left flank of each animal in the treated group three times. In the challenge phase, on Day 28, 0.3g of the test item was applied to the right flank of each animal in the control and treated group. 24 and 48 hours after the patch removal in each induction, the skin reactions were observed. 24 and 48 hours after patch removal in the challenge group, the skin reactions were observed and scored. Individual animal body weights were recorded on grouping day and at conclusion of the study.
Mortality: There were no deaths or moribund during the test.
Induction Phase: No abnormalities were found during the three times induction phase at the 24 hour observations after removing patches.
Challenge phase: No abnormalities were found in the control or treated animals observed at 24 and 48 hour observation. The score of skin reaction is 0 (0/20) for both 24 and 48 hour observation.
All animals showed expected gain in bodyweight during the study.
Based on the above results, E Stage 3 Intermediate was a non-sensitiser. The test result did not meet GHS criteria for skin sensitisation (BUEHLER)
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