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EC number: 849-166-3
CAS number: 83841-00-3
Table 1: details on aerosol concentrations
Percentage of sample collected on each stage
Geometric standard deviation
Generation of aerosol concentrations of the test substance using
the SAG generation device was variable, it was noted during generation
that the belt speed was often variable due to the test item blocking the
belt movement. This resulted in inconsistent achieved aerosol
The particle size distribution of the substance was determined under GLP
by cascade impaction in accordance with European Commission Technical
Guidance Document EUR 20268, Determination of Particle Size
Distribution, Fibre Length and Diameter Distribution of Chemical
The particle size distribution of the test substance was determined by
cascade impaction at a target aerosol concentration of 2.0 mg/L. The
study was performed in a flow through snout-only chamber. A solid
aerosol generator was used to generate the aerosols for the test. The
SAG mechanism technique for the dispersion of dry dust and powders
comprises two steps, the continuous supply of material to the disperser
and the dispersal of the material as an aerosol. The method for metering
powder to the disperser was to use a moving toothed belt. A regulated
flow of compressed air conducted the aerosol to the inhalation chamber.
The test system was housed in a ventilated cabinet. Aerosols were
collected with glass microfibre filters, held in an open faced filter
holder. The sample volume was measured by a wet-type gas meter. The
sample analysis was done by gravimetry. The particle size distribution
and mass median aerodynamic diameters (MMAD) were determined by cascade
impaction. Stainless steel substrates and glass microfibre final stage
filter were used. MMAD and geometric standard deviation were calculated
by linear regression of the probit of the cumulative percentage, by
mass, of particles smaller than the effect cut-off diameter (ECD) of
each stage versus the logarithm of the ECD of each stage. Generation of
aerosol concentrations of the test substance using the SAG generation
device was variable, it was noted during generation that the belt speed
was often variable due to the test item blocking the belt movement. This
resulted in inconsistent achieved aerosol concentrations.
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