Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 823-920-1
CAS number: 5341-95-7
Well 1 [OD570]
Well 2 [OD570]
Mean [OD570] (Well 1 and
Mean [OD570] blank corr. (Well 1 and
Mean [OD570] of T1 and T2
Tissue viabil.* [%]
rel. viabil. of T1 and T2**
Diff. of viabil. between T1 and T2 [p.p.]
* Tissue viability = [100 × meanOD blank corrected of T1&T2test
item / positve control / negative control]/[meanOD of T1&T2negative
** Relative Tissue viability = [100 × meanOD blank correctedtest
item / positive control / negative control]/[meanOD of T1&T2negative
This in vitro study was
performed to assess the eye irritation potential of 2,3-butanediol
((2R,3S)-rich) by means of the Human Cornea Model Test. The study was
conducted according to OECD 492 (adopted 2018) and in compliance with
GLP. Tissues of the human cornea model EpiOcular™ were treated with 50
μL of the test item, the positive and the negative control. The
viability was measured after 30 min exposure and 2 hours post-incubation.
Since the viability
value of the test item exposed tissues was 85.15% when compared to
negative control and hence did not decrease below 60%, the test item is
not considered to possess an eye irritating potential. This study
results were considered acceptable, because treatment with the positive
control induced a decrease in the mean tissue viability compared with
the negative control to 29.91%. The study was considered reliable and
adequate as part of the hazard assessment of eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again