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EC number: 823-920-1
CAS number: 5341-95-7
This in vitro study was
performed to assess the irritation potential of 2,3-butanediol
((2R,3S)-rich) by means of the Human Skin Model Test according to OECD
439 (adopted 2015). Each three tissues of the human skin model EpiDerm™
were treated with the test item, the negative control (DPBS) or the
positive control (5% SDS). The viability was measured after 60 min
exposure and 42 hours post-incubation.
After treatment with
the test item 2,3-butanediol ((2R,3S)-rich) the mean relative viability
value decreased to 89.80% compared to the relative absorbance value of
the negative control. This value is above the threshold for irritancy of≤50%.
Therefore, the test item is not considered to possess an irritant
potential. This study results were considered acceptable, because the
treatment with the positive control induced a sufficient decrease in the
relative absorbance as compared to the negative control for the 60
minutes treatment interval. The study was considered reliable and
adequate as part of the hazard assessment of skin irritation.
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