Registration Dossier
Registration Dossier
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EC number: 823-920-1 | CAS number: 5341-95-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- BASF test
- GLP compliance:
- no
- Test type:
- other: inhalation risk test (IRT)
- Limit test:
- no
Test material
- Reference substance name:
- Butane-2,3-diol
- EC Number:
- 208-173-6
- EC Name:
- Butane-2,3-diol
- Cas Number:
- 513-85-9
- Molecular formula:
- C4H10O2
- IUPAC Name:
- butane-2,3-diol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- saturated atmosphere (20°C); max 0.85 mg/L
- No. of animals per sex per dose:
- a total of 12 animals
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.85 mg/L air
- Based on:
- other: saturated atmosphere of the test item
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
- No mortality was observed when 12 rats were exposed for 7 h to an atmosphere that has been saturated at 20°C with the volatile part of the compound.
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