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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979-04-18 - 1980-12-22
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
BASF test
GLP compliance:
no
Test type:
other: BASF test
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Butane-2,3-diol
EC Number:
208-173-6
EC Name:
Butane-2,3-diol
Cas Number:
513-85-9
Molecular formula:
C4H10O2
IUPAC Name:
butane-2,3-diol
Test material form:
liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
no mortality
Clinical signs:
other: Dyspnea, Apathy, Staggering, Piloerection, Erythema, Exophthalmos, Poor general state

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on the available data the substance showed no mortality up to 5000 mg/kg bw.
Executive summary:

Based on the available data the substance showed no mortality up to 5000 mg/kg bw. Clinical signs were dyspnoea, apathy, staggering, piloerection, erythema, exophthalmos, and a poor general state.