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EC number: 439-210-6
CAS number: 554-62-1
Acute oral toxicity: LD50 > 5000 mg/kg (rat)
The acute oral toxicity of Phytosphingosine was assessed in rats
following a single administration of Phytosphingosine. The study was
performed in compliance with OECD guideline 401.
Groups of five males and five female fasted rats were given
Phytosphingosine as a single dose by oral gavage at a dose level of 5000
mg/kg. The acute oral median lethal dose (LD50) of Phytosphingosine was
estimated to be > 5000 mg/kg bw under the test conditions.
The study was considered reliable and adequate for hazard assessment of
A reliable key study is available investigating acute oral toxicity of
Phytosphingosine in rats according to OECD 401. The rats were exposed to
a single oral dose of the test item (5000 mg/kg) and observed during
post exposure. No mortality, significant clinical signs or macroscopic
changes were found in rats exposed to the test item (5000 mg/kg). LD50
is therefore reported as > 5000 mg/kg.
The submission substance does not need to be classified for acute
toxicity according to the criteria set out in the CLP Regulation. No
mortality, significant clinical signs or macroscopic changes were found
in rats exposed to the test item (5000 mg/kg).
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