(2S,3S,4R)-2-aminooctadecane-1,3,4-triol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes

Type of method:

column elution method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 62630012
- Expiration date of the lot/batch: 01.11.2002
- Purity: 94.0 %


STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature in the dark

Key result

Water solubility:

>= 0.001 - <= 0.004 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

0.5 g/L

Temp.:

20 °C

pH:

>= 6.4 - <= 8.5

Remarks on result:

completely miscible

Conclusions:

In conclusion, the water solubility of Phytosphingosine at 20.0 ± 1.0°C was measured to be between 1.4x10^-3 and 3.8x10^-3 g/I, using the column elution method. The geometric mean is 2.6 mg/L.

Executive summary:

The column elution method was used to determine the water solubility of Phytosphingosine and was based on the following guidelines:

OECD guideline for testing of chemicals no. 105: "Water Solubility", Adopted July 27, 1995. EEC Directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.6: "Water solubility". EEC Publication no. L383, December 1992. Several attempts were made to determine the water solubility of Phytosphingosine accurately. The results are shown in the table.

Column	Actual flow rate [ml/h]	Mean [mg/l]	pH
I	24.0	3.67	8.3
	12.0	3.81	8.3
II	24.0	1.36	8.5
	12.0	2.40	8.5
III	24.3	2.14	7.6
	12.0	2.07	7.8
IV	24.0	2.19	7.7
	11.9	2.11	7.8
V	24.3	3.28	6.4
	12.0	3.25	7.0
	24.6	3.22	6.6
VI	12.0	3.07	7.1

Based on these results it was decided to report water solubility of Phytosphingosine to be between 1.4x10^-3 and 3.8x10^-3 g/1 at 20.0 ± 1.0°C.

Description of key information

The water solubility of Phytosphingosine at 20.0 ± 1.0°C was measured to be between 1.4x10^-3 and 3.8x10^-3 g/L, using the column elution method. The geometric mean is 2.6 mg/L.

Key value for chemical safety assessment

Water solubility:

2.6 mg/L

at the temperature of:

20 °C