Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 439-210-6 | CAS number: 554-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 62630012
- Expiration date of the lot/batch: 01.11.2002
- Purity: 94.0 %
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature in the dark - Key result
- Water solubility:
- >= 0.001 - <= 0.004 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 0.5 g/L
- Temp.:
- 20 °C
- pH:
- >= 6.4 - <= 8.5
- Remarks on result:
- completely miscible
- Conclusions:
- In conclusion, the water solubility of Phytosphingosine at 20.0 ± 1.0°C was measured to be between 1.4x10^-3 and 3.8x10^-3 g/I, using the column elution method. The geometric mean is 2.6 mg/L.
- Executive summary:
The column elution method was used to determine the water solubility of Phytosphingosine and was based on the following guidelines:
OECD guideline for testing of chemicals no. 105: "Water Solubility", Adopted July 27, 1995. EEC Directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.6: "Water solubility". EEC Publication no. L383, December 1992. Several attempts were made to determine the water solubility of Phytosphingosine accurately. The results are shown in the table.
Column Actual flow rate [ml/h] Mean [mg/l] pH I 24.0 3.67 8.3 12.0 3.81 8.3 II 24.0 1.36 8.5
12.0 2.40 8.5 III 24.3 2.14 7.6 12.0 2.07 7.8 IV 24.0 2.19 7.7 11.9 2.11 7.8 V 24.3 3.28 6.4 12.0 3.25 7.0 24.6 3.22 6.6 VI 12.0 3.07 7.1 Based on these results it was decided to report water solubility of Phytosphingosine to be between 1.4x10^-3 and 3.8x10^-3 g/1 at 20.0 ± 1.0°C.
Reference
Description of key information
The water solubility of Phytosphingosine at 20.0 ± 1.0°C was measured to be between 1.4x10^-3 and 3.8x10^-3 g/L, using the column elution method. The geometric mean is 2.6 mg/L.
Key value for chemical safety assessment
- Water solubility:
- 2.6 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
