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EC number: 220-246-4
CAS number: 2687-12-9
An evaluation of the inherent properties of T000749 is performed against the ANNEX XIII criteria. If insufficient data were available, the screening criteria as laid down in ECHA Guidance on information requirements and chemical safety assessment Chapter R.11: PBT Assessment (2014) were applied.
The persistency assessment is based on the screening criteria in Annex XIII of the REACH Regulation. The biodegradation potential of the test substance has been assessed in a OECD 301D study (Desmares-Koopmans, 2016). The results reveal that the test substance degrades and the substance is considered to be readily biodegradable. It can therefore be concluded that based on the criteria mentioned above the substance is not persistent in the environment. The substance is concluded to be not P/vP.
The bioaccumulation assessment is based on the screening criteria in Annex XIII of the REACH Regulation. A measured Log Kow of 3.3 and 1.5 have been determined in an OECD 106 study (Reingruber, 2017) for the main component and main degradation product of the test item. Since the measured log Kow of the parent compound is below the criterium of log Kow < 4.5 no further assessment on bioaccumulation is needed. The test substance is concluded to be not B/vB.
The available evidence on the toxicity potential for the substance is sufficient for an assessment based on the Annex XIII criteria for this endpoint.
Based on an OECD 201 study, the ErC10 and NOErC values were higher than the cut-off value of 0.01 mg/L (34 mg/L and < 8.1 mg/L respectively). The test substance is not classified as carcinogenic or as a reproductive toxicant. It is classified as mutagenic Cat. 2 but not as a mutagenic Cat. 1A or 1B. However based on the available data and according to the criteria of the CLP Regulation, the test item should be classified as STOT RE category 2. Therefore it is concluded that the test item meets the Toxic (T) criteria.
As a conclusion, taking into account the conclusions that the substance is not P/vP, not B/vB and T. Hence, the substance should not be considered as a PBT/vPvB substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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