Registration Dossier
Registration Dossier
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EC number: 947-377-6 | CAS number: -
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- run on 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR prediction: The values obtained on known constituents of the substance are not experimental results, however the QSAR model is recommended by the ECHA guidance document on information requirements, and is well documented with regard to validation parameters according to OECD principles. Moreover, the constituents of the substance are fully characterised and are towards the applicability domain of the model except two constituents with a logKow above the validated range reported in the Training set. It is nevertheless an indication of solubility of a part of the substance tested.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
- Principles of method if other than guideline:
- QSAR estimation
Test material
- Reference substance name:
- Extract of Boswellia serrata (Burseraceae) obtained from exudate by solvent extraction
- EC Number:
- 947-377-6
- IUPAC Name:
- Extract of Boswellia serrata (Burseraceae) obtained from exudate by solvent extraction
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- >= 0 - <= 0.012 mg/L
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not reported
- Details on results:
- pH not reported, no Melting point used.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: A part of the composition of the substance is insoluble in water (<0.1 mg/L)
- Executive summary:
The water solubility of the known constituents of the substance was estimated using the recommended QSAR model WSKowWin v1.42. Even if the results shall be considered with restrictions due to the type of information (QSAR) and considering that two constituents are outside the applicability domain of the model (estimated logKow above the range of logKow in the Training set), the results are nevertheless an indication of solubility of the part of the identified substance. The calculated water solubility of the known constituents of the substance was estimated between about 4.10 -5 and 0.01222 mg/L at 25°C.
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