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Physical & Chemical properties

Boiling point

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boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26 September - 23 October 2017
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised. Therefore full validation applies.
according to guideline
OECD Guideline 103 (Boiling Point)
Version / remarks:
dated 27. Jul. 1995
according to guideline
EU Method A.2 (Boiling Temperature)
Version / remarks:
Regulation (EC) No440/2008 of 30 May 2008, published on 31. May 2008
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
GLP compliance programme (inspected on 13-14 October 2014 / signed on 8 April 2015)
Type of method:
method according to Siwoloboff
and DSC method
Boiling pt.:
205.5 °C
Atm. press.:
>= 100.256 - <= 100.276 kPa
Decomp. temp.:
>= 95 °C


Pre-test for the boiling point following Siwoloboff

Observations Pre-test for the boiling point following Siwoloboff



started to slightly shrivel, colour getting darker

95 °C

melted to a slightly yellowish sticky mass and stay for a long time in this state

122 °C

Getting more transparent with a colourless condensate

130 °C

Test item slightly expanded upward with fine foam

Since 140 °C

At the bottom part had more foam than at the top part

160 °C

Bubbles were visible

190 °C

A brown liquid at the bottom with foam at the surface

200 °C

Test item boiled with a lots of foam

250 °C

No foam anymore, test item was a dark brown liquid and boiled

360 °C

Performance of heating and turned off the burner

Up to 400 °C

After cooling down the test item was a dark-brown solid.

Test for boiling point following DSC method

DSC measurements showed only an increase in the heat flow at 359.53 °C. After the test the crucible was visually unchanged, the crucible was opened and a very small amount of whitely to yellow discolored residue was visible. However, no boiling point can be determined using this method.

Finally, the determination of boiling point was conducted using Siwoloboff Method.

Main test : Boiling Point following Siwoloboff method:


Boiling Point

Atmospheric Pressure

First determination

205.2 °C (478.4 K)

100276 Pa

Second determination

205.7 °C (478.9 K)

100256 Pa


Mean ± standard deviation (without correction following Sydney Young)

=205.5 °C ± 0.4 °C (478.6 ± 0.4 K).


Observations Boiling Point following Siwoloboff






Test item melted instantly to a yellow-orange mass under strong expanding and foaming

190 °C

190 °C

Formation of bubbles, the test item was like a very viscous orange-brown liquid caramelised syrup

213 °C

212.9 °C

Strong foaming, boiled with a lots of bubbles.

Due to the high viscosity of the test item no rising back into the capillary was visible.

238.4 °C

238 °C

turned off burner, test item was dark brown

247.1 °C

246 °C

No more bubbles

205.2 °C

205.7 °C


After cooling down the test item solidified as dark brown mass.

Some of this mass from the second determination was taken to grind, no significant change was visually observed only the test item after the determination seemed to be slightly darker.

We noted potential degradation of the substance starting possibly from 95 °C according to the observations reported in the pre-test.

The boiling point under possibly decomposition can be stated as 205.5°C (mean value, between 100.256 and 100.276 kPa), with potential decomposition of the substance starting from about 95°C.
Executive summary:

A study was conducted under GLP according to EU Method A.2 and OECD 103, using Siwoloboff method to determine the boiling point of the substance.

Siwoloboff pre-test and DSC measurements were performed to determine the method to be used to determine the initial boiling point of the substance. Finally two independant determinations were conducted using Siwoloboff method and the mean value was used to determine the boiling point of the substance.

Description of key information

The boiling point was determined as 205.5°C (between 100.256 and 100.276 kPa) with potential degradation of the substance starting from about 95 °C

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
205.5 °C

Additional information

A fully reliable GLP experimental study, conducted according to a recognized OECD/EC guidelines using Siwoloboff method, is available.

It is considered as a key study. The result is retained as key data.