Registration Dossier
Registration Dossier
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EC number: 292-324-6 | CAS number: 90604-31-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID Dataset for the CAS: 90604-31-2
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID Dataset, EUROPEAN COMMISSION – European Chemicals Bureau, 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/EEC, B.4 "Acute toxicity (skin irritation)"
- Principles of method if other than guideline:
- The dermal irritation potential of Alcohols, C13-C15 was evaluated in rabbits following the method prescribed in Directive 84/449/EEC, B.4 "Acute toxicity (skin irritation)"
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Alcohols, C13-15
- EC Number:
- 292-324-6
- EC Name:
- Alcohols, C13-15
- Cas Number:
- 90604-31-2
- Molecular formula:
- C15H32O
- IUPAC Name:
- Alcohols, C13-15
- Test material form:
- liquid
- Details on test material:
- - Name of test material: Alcohols, C13-15
- IUPAC name: Alcohols, C13-15
- Molecular formula:C15H32O
- Molecular weight: 228 g/mole
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: Alcohols, C13-15
- IUPAC name: Alcohols, C13-15
- Molecular formula: C13H280 + C15H32O
- Molecular weight: 208.78 g/mole
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- No data available
- Observation period:
- No data available
- Number of animals:
- No data available
- Details on study design:
- No data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- No data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: No data available
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Moderate irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Alcohols, C13-C15 causes moderate irritation to rabbit skin.
Hence, Alcohols, C13-C15 can be considered to be irritating to skin. - Executive summary:
The dermal irritation potential of Alcohols, C13-C15 was evaluated in rabbits following the method prescribed in Directive 84/449/EEC, B.4 "Acute toxicity (skin irritation)".
Alcohols, C13-C15 was applied to the skin of rabbits and observed for signs of irritation (dose, duration and observation period not mentioned).
Alcohols, C13-C15 causes moderate irritation to rabbit skin.
Hence, Alcohols, C13-C15 can be considered to be irritating to skin.
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