Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 614-345-5 | CAS number: 68155-40-8
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The partition coefficient of the test substance is 3.4 (log Pow), using data from a similar substance in a category approach.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.4
- at the temperature of:
- 25 °C
Additional information
The registered substance is a surface active with a surface tension of 27 mN/m at 20C and 1000 mg/L. For surfactants,measurement of the Kow is challenging or in most cases infeasible (see REACH Guidance R.7.8.1.). The registrant has managed to measure the Kow under the conditions described in the end-point robust study summary with the slow-stirring method. Other conditions were found to be infeasible. The conditions used in the slow-stirring test are environmentally relevant (pH range to be considered is 4-9). Based on the pKa of 8.8, the registered substance does not exist exclusively in a neutral form within this environmentally relevant pH range.
The log Kow is regarded as an essential data point within the chemical safety assessment e.g. to estimate water solubility, adsorption/desorption and bioaccumulation in fish. For the registered substance measured values for water solubility (as Critical Micelle Concentration in IUCLID Chapter 4.8) and measured sorption constants (see IUCLID Chapter 5.4.1) are available. Therefore estimation of these parameters with help of Kow is not necessary. As the registered substance is a cationic surfactant measurement of the BCF in an OECD 305 test is not feasible as the cationic substance strongly sorbs to the negatively charged mucous of the fish. This statement is based on an attempt to measure the BCF fish for 1-Hexadecanammonium chloride which failed. The currently best method to estimate the BCF of a cationic substance is the ADME Model of Arnot and Gobas BCFBAF implemented in the US EPA EPIWIN Suite. This ADME model takes into account adsorption, distribution, metabolism and excretion of a substance and not only the distribution e.g. based on the log Kow alone.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
