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EC number: 614-345-5
CAS number: 68155-40-8
Dose level (mg/kg bw)
A study was performed to determine the acute
oral toxicity of the test material in the Sprague-Dawley CFY strain rat.
The study was designed to comply with the recommendations o f the OECD
Guidelines for Testing of Chemicals (1981) No. 401 "Acute Oral
Toxicity". Following a range-finding study, four groups, each of ten
fasted animals (five males and five females) were given a single oral
dose of undiluted test material, at dose levels of 1000
t o 2000 mg/kg bodyweight. Deaths were noted
two to three days after treatment. Major signs of toxicity noted during
the day of dosing were hunched
posture, pilo-erection, lethargy , decreased
respiratory rate, increased salivation and ptosis. Less frequent signs
of ataxia, pallor of the extremities, diarrhoea, diuresis,
chromodacryorrhoea, tiptoe gait, emaciation, red/brown staining around
the snout/eyes were also noted. Signs of reaction continued to be noted
up to three to fourteen days after treatment. Surviving animals treated
with 1000 mg/kg showed expected body weight gains
over the study period. Effects on body
weight were noted in other dose groups during the first week but all
animals recovered to show expected
body weight gains over the second week.
Necropsy of decedents revealed congested or abnormally red lungs, dark
livers , haemorrhage of the gastric mucosa with congestion of the small
intestines. Necropsy of animals killed at the end of the study revealed
thickened or raised white areas on the non-glandular region of the
stomach. The acute oral median lethal dose (LDS0) and 95% confidence
limits were found to be:
All animals: 1260 (1053 - 1508) mg/kg body
Males only: 1309 (1024 - 1674) mg/kg body
Females only: between 1000 and 1587 mg/kg
body weight (best estimate).
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