Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 614-345-5
CAS number: 68155-40-8
Dose level (mg/kg bw)
A study was performed to determine the acute
oral toxicity of the test material in the Sprague-Dawley CFY strain rat.
The study was designed to comply with the recommendations o f the OECD
Guidelines for Testing of Chemicals (1981) No. 401 "Acute Oral
Toxicity". Following a range-finding study, four groups, each of ten
fasted animals (five males and five females) were given a single oral
dose of undiluted test material, at dose levels of 1000
t o 2000 mg/kg bodyweight. Deaths were noted
two to three days after treatment. Major signs of toxicity noted during
the day of dosing were hunched
posture, pilo-erection, lethargy , decreased
respiratory rate, increased salivation and ptosis. Less frequent signs
of ataxia, pallor of the extremities, diarrhoea, diuresis,
chromodacryorrhoea, tiptoe gait, emaciation, red/brown staining around
the snout/eyes were also noted. Signs of reaction continued to be noted
up to three to fourteen days after treatment. Surviving animals treated
with 1000 mg/kg showed expected body weight gains
over the study period. Effects on body
weight were noted in other dose groups during the first week but all
animals recovered to show expected
body weight gains over the second week.
Necropsy of decedents revealed congested or abnormally red lungs, dark
livers , haemorrhage of the gastric mucosa with congestion of the small
intestines. Necropsy of animals killed at the end of the study revealed
thickened or raised white areas on the non-glandular region of the
stomach. The acute oral median lethal dose (LDS0) and 95% confidence
limits were found to be:
All animals: 1260 (1053 - 1508) mg/kg body
Males only: 1309 (1024 - 1674) mg/kg body
Females only: between 1000 and 1587 mg/kg
body weight (best estimate).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Sellel veebilehel kasutatakse küpsiseid, et tagada lehe parim kasutus.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again