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Diss Factsheets
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EC number: 203-856-5 | CAS number: 111-30-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- eye irritation
- respiratory irritation
- Principles of method if other than guideline:
- The study assessed daily, both objectively and/or subjectively, the ocular and respiratory irritation experienced by the same 12 subjects.
- GLP compliance:
- no
Test material
- Reference substance name:
- Glutaral
- EC Number:
- 203-856-5
- EC Name:
- Glutaral
- Cas Number:
- 111-30-8
- Molecular formula:
- C5H8O2
- IUPAC Name:
- glutaraldehyde
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Cidex activated dialdehyde solution & Sporicidin cold sterilizing solution.
- Composition of test material, percentage of components: unknown. active ingredient ca 2%
Method
- Type of population:
- general
- Subjects:
- A panel of 12 subjects, 9 females and 3 males, started and completed the study
- Ethical approval:
- confirmed and informed consent free of coercion received
- Route of exposure:
- inhalation
- ocular
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Details on exposure:
- The test panel was placed in a closed room and were exposed to an individual test substance each day. A different test solution was used on each of the five exposure days. Containers with the test material were placed in the room at 2 or more locations and were agitated and in total 8 hours of exposure took place.
- Examinations:
- To asses if any effects occured in between test days (minimum of 48 hrs) a questionaire including eye and respiratory irritaion questions was executed prior to each test day. The questionaire was followed by an occular examination. When irritation developed during exposure the subject was removed and interviewed. All subjects were screened and examined prior and at the end of the 8 hour exposure period.
Results and discussion
- Results of examinations:
- Cidex: The panel was exposed to Cidex on the first two exposure days. On the first exposure day 1/12 reported dryness of nose, 1/12 dryness of throat, 2/12 burning of eyes, 2/12 itching of eyes, 1/12 watery eyes and 10/12 detected odor. On the second exposure day 1/12 reported irritation of the nose, 1/12 burning of eyes, 1/12 stinging of eyes, 1/12 itching of eyes, 1/12 watery eyes and 11/12 detected odor.
Sporicidin: The panel was exposed to Sporicidin on the last exposure day (fifth). 1/12 reported watery eyes and 11/12 detected odor. No other effects were reported.
For both test materials, lachrymation, palpebral conjuctiva redness, and bulbar conjunctiva redness were not observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.