Lupine, L. albus, ext.

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

24 June 2016 to 03 August 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore, full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

no

Type of method:

effusion method: Knudsen cell

Key result

Temp.:

ca. 120 °C

Vapour pressure:

< 0.001 Pa

Remarks on result:

not determinable because of methodological limitations

Remarks:

The vapour pressure of the test item was considered to be lower than 10-3 Pa at 120 °C and as a consequence largely lower than 10-3 Pa at 20 °C. This value of 10-3 Pa corresponds to the minimal limit of pressure determined by our apparatus.

Table 4.6/1: Results of vapour pressure determination

The mass of sample weighed for each assay was reported in the table below. The sample was placed in a Knudsen effusion cell. Then the cell was placed in the apparatus.

Assay No.	Test temperature t(°C)	Mass of test item weight (mg)	dm/dT (mg/min)	Knudsen effusion cell aperture size(µm)	Taken into account or not
1	85	2.09	/	279.9	No
2	85	2.09	/	279.9	No
3	85	1.55	/	279.9	No
4	85	1.73	3.6624 x 10-4	279.9	Yes
5	120	1.73	5.5929 x 10-4	279.9	Yes

For the assays No. 1, 2 and 3, no trace of loss of weight was recorded as a part of the balance was broken.

For the assays No. 4 and 5, no loss of weight was recorded neither at 85 °C nor at 120 °C. No degradation of the test item was observed after the experiment; the powder remained yellow. The vapour pressure of the test item was considered to be lower than 10-3 Pa at 120 °C and as a consequence largely lower than 10-3 Pa at 20 °C. This value of 10-3 Pa corresponds to the minimal limit of pressure determined by our apparatus.

Conclusion

The vapour pressure of the test item was considered to be lower than 10-3 Pa at 120 °C and as a consequence largely lower than 10-3 Pa at 20 °C.

Conclusions:

The vapour pressure of the test item was considered to be lower than 10-3 Pa at 120 °C and as a consequence largely lower than 10-3 Pa at 20 °C.

Executive summary:

The vapour pressure of the test substance was measured according to OECD 104 / EU A4 guideline using a effusion method weight loss. Five determinations were conducted at 85°C (4 determinations) and 120 °C ( 1 determination). The vapour pressure of the test item was considered to be lower than 10-3 Pa at 120 °C and as a consequence largely lower than 10-3 Pa at 20 °C.

Description of key information

Low volatility

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method , is available. It is considered as a key study.

The vapour pressure of the test item was considered to be lower than 10-3 Pa at 120 °C and as a consequence largely lower than 10-3 Pa at 20 °C.

Five determinations were conducted at 85 and 120 °C and loss of weight was recorded.