Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-742-4
CAS number: 865-49-6
In a chromosomal aberration assay, groups of 3 male Long-Evans rats were
treated orally (gavage) with chloroform (dissolved in redistilled water
and physiological saline) at doses of 1.2, 11.9, and 119.4 mg/kg
bodyweight once daily for five consecutive days.
One group of 3 males, acting as control group, received the vehicle
(physiological saline solution) and another group of 3 males received
the positive control test item (potassium bromate) at the dose-level of
250.5 mg/kg, under the same experimental conditions than the chloroform
The animals were killed 18 hours after receiving the last dose to study
the frequency of aberrant metaphase cells in femoral bone marrow cells.
Compared to control group, a dose-related increase in the incidence of
aberrant cells and of the number of aberration per cell was observed.
This difference was statistically significant at the high dose (6%
versus 1% for the controls). Various times of sampling (6, 12, 18 and 24
hours after the last dosing) were also performed at the high dose and
indicated that the incidence of aberrant cells increased gradually to
reach a maximum level 18 hours after the last treatment. No more
increase was observed 24 hours after the last treatment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again