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EC number: 212-742-4
CAS number: 865-49-6
Table 1: Mortality occurring in the acute oral toxicity study:
Total animals dead*
Survival time (days after oral administration)
*Animals dying before the end of the 14 day observation period
Table 2: Incidence of histological changes of rats which survived single
oral doses of chloroform
Numbers denote: number of animals showing lesions/animals examined
The acute oral toxicity of chloroform, solubilised in corn oil, was
tested in female and male Sprague-Dawley rats (10 animals per dose
group) in accordance with the OECD Guideline No. 401 with minor
restrictions. Chloroform was administered at doses of 546, 765, 1071,
1500 and 2100 mg/kg body weight by oral gavage. Animals were then
observed for 14 hours, clinical signs were noted and animals which were
dying during the observation period or were killed after 14 days were
submitted to necropsy and gross pathology. The mean LD50 values
determined for male rats was 908 mg/kg body weight, that of female rats
was 1117 mg/kg. Following the GHS classification system, chloroform on
the basis of the present study is classified into Toxicity Category IV,
receiving the hazard statement "harmful if swallowed".
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