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EC number: 203-131-3
CAS number: 103-64-0
The reaction was evaluated at 24 ,4
8 and 72 h after challenge. According to the following criteria and
scores in parentheses: .
-no reaction (0).
± slight erytherna (1)
+apparent erytherna (2).
+ apparent erythema with edema (3):
+ crust or necrosis (4).
Greater than a + reaction was
considered to be positive.
Score after 1st and 2nd challenge
Challenge conc.%(w/w) 2ndchallenge
24-h 48-h 72-h
Positive number/Total numberand mean
response (score)in parenthesis.
The test chemical was assessed for its
possible contact allergenic potential by AP2 in female guinea pigs.
For this purpose induction exposure
was performed as 24-h occlusive patch at the 2 x 4 cm site on the
scapular region with the occlusive patch unit containing 0.2 ml of
test solution at concentration of 10%. Before challenge exposure test
animals were treated with 0.1 ml of FCA (undiluted) i.d. injection
into 2 sites in the scapular region 7 days before the test. After
non-occlusive topical application challenge, animal were placed
individually or 1 to 2 h0ur (long enough for drying) in 5 series
of cages allowing no interference. After a rest period of 11 and 32 and
39 days respectively 1st, 2ndand 3rdchallenge were performed .The
flank skin was clipped and shaved. The 1st and 2nd challenges were
carried out by non-occlusive topical application. 0.02 ml of
test solution were applied to 2.0 cm diameter areas of the flank skin
with a silicone stick (0 = 5.0 mm) using a test Concentrations of 30%,
10%,3%. The 3rdchallenge was performed by occlusive topical application
of 0.1 ml at the concentration 0.1%, 0.03%, 0.01%.The reaction was
evaluated at 24, 48 and 72 h after challenge
After third challenge, the test
chemical showed positive result for the test concentration 0.1% as
the evaluated score was in the range of 3.2. While for the other two
concentration 0.03% and 0.01% the evaluated score for sensitization was
3.0 and 2.8 respectively.
Thus according to AP2 test, the test
chemical was observed to be sensitizing in guinea pigs at the tested
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