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EC number: 203-131-3
CAS number: 103-64-0
No signs of eye irritation were observed in
rabbit using 0.1 ml of undiluted test material.
The ocular irritation study of test
chemical was conducted in four female SPF albino rabbits to assess the
irritation potential of test chemical.
A dose volume of 0.1 ml was instilled
into one eye. The untreated eye of each animal served as a control.
Observations were made at 1, 48, 72 h and 7 days after treatment. At 24
h after dosing, corneal opacity was scattered or diffuse on more than
one quarter but less than one half of the cornea. Application of
fluorescein confirmed this finding. The conjunctiva were still diffuse,
crimson red with individual vessels not easily discernible, swelling was
still noted as well as an abnormal discharge. At 48 h after dosing, the
scattered or diffuse area of opacity was still noted on one quarter or
less of the cornea, even after instillation of fluorescein. The
conjunctiva was still diffusely red; the individual vessels were not
easily discernible and abnormal swelling still present.
At 72 h after dosing, the conjunctival
vessels were still injected and following the instillation of
fluorescein a scattered or diffuse area of opacity on one quarter or
less of the cornea was noted. By 7 days after dosing the animals were
free of any signs of eye irritation. Since the observed effects were
cleared within the observation period of 7 days, the test chemical was
considered as not irritating to the eyes of treated rabbits.
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