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EC number: 232-077-3
CAS number: 7785-26-4
The test item alpha-pinene
multiconstituent was administered to a group of 3 female Sprague
Dawley rats at the dose of 2000 mg/kg body weight and then to a group of
6 female Sprague Dawley rats at the dose of 300 mg/kg body weight. The
experimental protocol was established according to the official method
as defined in the O.E.C.D. Test Guideline No. 423 dated December 17th,
2001 and the test method B.1tris of the Council regulation No. 440/2008.
Three mortalities were noted in
animals treated at the dose of 2000 mg/kg body weight, at 24 hours
The mortalities were preceded by a
decrease in spontaneous activity (1/3) at 30 minutes post-dose. No other
signs of systemic toxicity were noted.
Rigor mortis were noted before the
necropsy in two animals (2/3). The macroscopic examination of the
animals revealed a thinningof the corpus (2/3).
No mortality was noted in the animals
treated at the dose of 300 mg/kg body weight.
No clinical signs related to the
administration of the test item were observed during the study.
The body weight evolution of the
animals remained normal throughout the study.
The macroscopic examination of the
animals at the end of the study did not reveal treatment related
In conclusion, the LD50 of
test item alpha-pinene multiconstituent is
higher than 300 mg/kg body weight and lower than
2000 mg/kg by oral route in the rat.
In accordance with guideline OECD 423,
the LD50 cut-off of the test item may be considered as 500
mg/kg body weight by oral route in the rat.
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