Registration Dossier
Registration Dossier
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EC number: 203-571-6 | CAS number: 108-31-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD TD 107) with GLP standard.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Maleic anhydride
- EC Number:
- 203-571-6
- EC Name:
- Maleic anhydride
- Cas Number:
- 108-31-6
- Molecular formula:
- C4H2O3
- IUPAC Name:
- furan-2,5-dione
- Details on test material:
- Hydrolysis to maleic acid occurs in aqueous conditions, so test substance was likely a mixture of maleic anhydride, maleic acid and its sodium and
potassium salts, thus the analyte was maleic acid.
Constituent 1
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- -2.36
- Temp.:
- 19.8 °C
- pH:
- 4
- Type:
- log Pow
- Partition coefficient:
- -2.78
- Temp.:
- 19.8 °C
- pH:
- 7
- Type:
- log Pow
- Partition coefficient:
- -2.68
- Temp.:
- 19.8 °C
- pH:
- 9
- Details on results:
- No evident variation (differs less than 0.5 unit from pH 4 to 9) occurs with pH , so the average value is used as logP, which is -2.61.
Applicant's summary and conclusion
- Conclusions:
- logP is -2.61 at 20°C.
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