Registration Dossier
Registration Dossier
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EC number: 205-205-0 | CAS number: 135-61-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD Guideline, no deviation, GLP Study, scientifically sound
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 3-hydroxy-2'-methyl-2-naphthanilide
- EC Number:
- 205-205-0
- EC Name:
- 3-hydroxy-2'-methyl-2-naphthanilide
- Cas Number:
- 135-61-5
- Molecular formula:
- C18H15NO2
- IUPAC Name:
- 3-hydroxy-N-(2-methylphenyl)naphthalene-2-carboxamide
- Reference substance name:
- Naphtol AS-D
- IUPAC Name:
- Naphtol AS-D
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- dimethyl sulphoxide
- Concentration:
- 0.1, 0.2, 0.4. 1 and 5 %
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- EC3 = 18.2 % using acetone:olive oil as vehicle
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: The S.I were 1.64, 2.41, 2.79, 5.52 and 4.71 for concentrations of 0.1, 0.2, 0.4, 1 and 5% respectively.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- Naphtol AS-D was found to be a skin sensitizer in LLNA using DMSO as vehicle. The obtained EC3 was 0.4% (w/v).
- Executive summary:
The skin sensitizing potential of Naphtol AS-D was investigated in LLNA using DMSO as vehicle.
At concentrations of 0.1, 0.2, 0.4, 1 and 5% the Stimulations indexes were 1.64, 2,41, 2.79, 5.52 and 4.71 respectively.
Naphtol AS-D was found to be a skin sensitizer. The estimated EC3 was 0.4 %.
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