Registration Dossier
Registration Dossier
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EC number: 205-205-0 | CAS number: 135-61-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Short report, limited documentation, non-GLP, females only
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- females only, limit dose = 5000 mg/kg
- GLP compliance:
- no
- Remarks:
- pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-hydroxy-2'-methyl-2-naphthanilide
- EC Number:
- 205-205-0
- EC Name:
- 3-hydroxy-2'-methyl-2-naphthanilide
- Cas Number:
- 135-61-5
- Molecular formula:
- C18H15NO2
- IUPAC Name:
- 3-hydroxy-N-(2-methylphenyl)naphthalene-2-carboxamide
- Reference substance name:
- Naphtol AS-D
- IUPAC Name:
- Naphtol AS-D
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: 1/week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsy
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: Limit test
- Mortality:
- none detected
- Clinical signs:
- other: none detected
- Gross pathology:
- no effects
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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