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EC number: 295-458-3
CAS number: 92045-76-6
A complex combination of hydrocarbons obtained from residual oils by solvent crystallisation and treated with hydrogen in the presence of a catalyst. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C25.
Table 1. Micronucleus Tests of Mineral Hydrocarbons in Female CD-1 Mice (micronucleus frequency ± st dev)
20 mg/kg cyclophosphamide
**Significantly different from control at p<0.01
Positive control tested at 24 hours only
Table 2. Micronucleus Tests of Mineral Hydrocarbons in Male CD-1 mice
for Read Across
substance is similar
to the feedstocks for most of current dewaxing operations that produce
the finished paraffin and microcrystalline waxes. These lubricant base
oil data may serve as the basis for a worst case assessment of the
reproductive potential of paraffin and microcrystalline waxes and are
summarised in this section.
In a CD-1 mouse bone marrow
micronucleus assay, male and female mice were given a single
intraperitoneal injection of 5 different paraffin oils in corn oil
vehicle at doses of 0, 1.0, 2.5, or 5.0 g/kg. Bone marrow cells were
harvested at 24, 48, and 72 hours post-dosing. One animal did not
survive to scheduled sacrifice, but there were no gross signs of
toxicity. The micronucleus frequency was significantly greater than
the concurrent negative control in bone marrow cells of male mice
given 5.0 g/kg at 48 hours post-dosing, but the negative control was
unusually low in this instance, and therefore this result is not
This study received a Klimisch score
of 1 and is classified as reliable without restriction because it
closely adhered to OECD Test Guideline 474.
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