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EC number: 295-458-3
CAS number: 92045-76-6
A complex combination of hydrocarbons obtained from residual oils by solvent crystallisation and treated with hydrogen in the presence of a catalyst. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C25.
In toxicokinetic studies analyzing tissue distribution paraffin and hydrocarbon waxes accumulated in the greatest amounts in the liver and mesenteric lymph nodes. The majority of the administered dose of these substances is excreted in the urine and faeces. Results indicated that typically around 10% of the total dose gets absorbed.
In toxicokinetic studies analyzing tissue
distribution, paraffin and hydrocarbon waxes were found in the greatest
amounts in the liver and mesenteric lymph nodes and in smaller amounts
in the kidneys and spleen. The majority of the administered dose of
these substances is excreted in the urine and faeces. Results indicate
that typically around 10% of the total dose gets absorbed. Differences
in the pharmacokinetic activity of waxes were seen between males and
females. Different components of the test substances also exhibit
different pharmacokinetic activity.
In a key tissue distribution toxicokinetic
study (Klimisch score = 2), groups of 4 week old Fischer 344 rats (5 per
sex) were fed a control diet or diets containing one of five
microcrystalline or paraffin waxes (low melting point wax, intermediate
melting point wax, high melting point wax, mix of high and low melting
point wax, and high sulphur wax) for 90 days at a concentration of
20,000 ppm. Extra groups of rats (5 per sex), used to determine whether
effects were reversible, were fed control diet or one of 5 waxes for 90
days followed by exposure to control diet only for an additional 28 to
85 days. The waxes were distributed mostly in the liver, mesenteric
lymph nodes, and perirenal fat. Less than 0.1 mg/g was distributed in
the spleen and kidneys. Accumulation of the waxes in the liver and
mesenteric lymph nodes was greater in females than males. After a 85
-day reversal period, the accumulation levels in the liver decreased by
80 to 90%. However, there was minimal reduction of the wax accumulation
in the mesenteric lymph nodes after a 28 -day reversal period. Data from
the 85 -day reversal period in the mesenteric lymph nodes was not
In a toxicokinetics study (Klimisch score =
2), distribution, excretion, and metabolite activity was monitored in
female Sprague Dawley and F-433 rats following oral administration by
gavage either 1.8 g/kg or 0.18 g/kg of [1 -14C]1 -eicosanylcyclohexane,
a mineral hydrocarbon, in olive oil. Blood, urine, faeces, liver, and
mesenteric lymph nodes were analyzed for the radiolabelled test
substance and it's metabolites. Livers and mesenteric lymph nodes of
F-344 rats retained a greater percentage of mineral hydrocarbons than
did Sprague-Dawley rats. Faecal excretion was the major route of
elimination for both strains and doses. 92 and 88% of the administered
high dose was recovered in 96 hours the F-344 and Sprague-Dawley rats,
respectively. The amount of radioactivity removed in the urine was
dose-dependent in both strains. The major urinary metabolite identified
in both Sprague-Dawley and F-344 rats was 12 -cyclohexyldodecanoic acid.
10 -cyclohexyldodecanoic acid was also identified.
In a tissue disposition study (Klimisch
score = 2) male and female F-344 rats were fed a diet of 20,000 ppm dose
(2% w/w) of naphthenic white oil with radiotracer surrogates for each
chemical class, during a one hour feeding session. Cycloparaffinic,
isoparaffinic, and n-paraffinic components of the white oil were
radiolabelled and accumulation was analyzed in the liver, mesenteric
lymph nodes, spleen, adipose tissue, brain, blood, urine, and faeces.
Three animals were sacrificed at 2, 4, 8, 16, 24, 48, and 72 hours.
Results indicate that n-paraffins are less readily absorbed than either
cycloparaffins or isoparaffins. Cycloparaffins are the most extensively
absorbed component of the white oil, they are found at higher
concentrations in the liver and mesenteric lymph nodes than
isoparaffins. There was so significant difference in the absorption and
distribution response of males and females.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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