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EC number: 295-458-3
CAS number: 92045-76-6
A complex combination of hydrocarbons obtained from residual oils by solvent crystallisation and treated with hydrogen in the presence of a catalyst. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C25.
Skin Irritation (number affected/number examined)
Dose Groups (mg/kg/day)
Flaking of Skin
for Read Across
substance is similar
to the feedstocks for most of current dewaxing operations that produce
the finished paraffin and microcrystalline waxes. These lubricant base
oil data may serve as the basis for a worst case assessment of the
reproductive potential of paraffin and microcrystalline waxes and are
summarised in this section.
Dermal application of the lubricant base oil
to pregnant rats during gestation produced slight dermal irritation at
all dose levels. At these dosages, the lubricant base
oil produced erythema and flaking of the skin at the site of application
in a dose-dependent manner. One animal in the 500
mg/kg/day dose group had dermal oedema.
There was no evidence of teratogenicity.
There were no treatment-related changes observed during the external,
skeletal, or visceral evaluations. Mean foetal weight and crown-rump
lengths were comparable across all dose groups. A
developmental/teratogenic NOAEL was not reported; however, it can be
inferred that this value is ≥2000
study received a Klimisch score of 1 and is classified as reliable
without restriction because this study is compliant with OECD Guideline
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