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EC number: 295-458-3
CAS number: 92045-76-6
A complex combination of hydrocarbons obtained from residual oils by solvent crystallisation and treated with hydrogen in the presence of a catalyst. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C25.
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substance is similar to the feedstocks for most of current dewaxing
operations that produce the finished paraffin and microcrystalline
waxes. These lubricant base oil data may serve as the basis for a worst
case assessment of the reproductive potential of paraffin and
microcrystalline waxes and are summarised in this section.
a dermal carcinogenicity study, male C3H/HeNCrlBR mice (50/group) were
dermally exposed to a lubricant base oil (designated MRD-87-016) and the
appropriate controls at a frequency of twice per week for 24 months or
until observation of carcinoma at which time the animal was sacrificed.
The dermal application of the test material produced considerable
irritation in groups 951 (positive control) and 722 (vehicle control).
This irritation was noted macroscopically as desquamation, exfoliation,
atonia, eschar, erythema and/or edema. Microscopic examination revealed
acanthosis and subepidermal inflammatory infiltrate. Treatment group 016
and the negative control group 721 were generally free of dermal
irritation during most of the study and at histopathological
examination. Forty-five of the fifty Group 951 animals (positive
control) had confirmed squamous cell carcinomas at histopathology. All
other groups were free of any skin neoplasms. With the exception of the
positive control group, there were no statistical differences in time to
tumour and tumour production between groups. Survivorship analysis
indicated that the positive control displayed the lowest survivorship;
however, this finding is related to the fact that animals were
euthanized following the appearance of a carcinoma. Gross postmortem
examination showed a high incidence of liver masses in all groups except
951. These liver masses as well as other lesions noted
histopathologically were of the usual type and incidence in this strain
and age and were considered to be unrelated to treatment. Therefore, the
test material did not cause local or systemic effects when applied neat.
NOAEL was determined to be ≥150
mg/kg/day, based on the lack of treatment-related histopathology or
gross pathology changes observed in the study.
study received a Klimisch score of 1 and is classified as reliable
without restriction because it was carried out according to TG 453.
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