Registration Dossier
Registration Dossier
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EC number: 402-810-3 | CAS number: 17980-47-1 DYNASILAN BH N; DYNASILAN BSM 100 N; DYNASILAN NH 42
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
This is the only reproductive toxicity study available for this substance.
Short description of key information:
In a rat oral one-generation reproductive toxicity study conducted to OECD 415 and to GLP (Safepharm Laboratories Ltd., 1992) the NOAEL for parental general toxicity and for reproductive toxicity for triethoxyisobutylsilane was at least 1000 mg/kg bw/day, as no adverse effects were observed at any dose.
Effects on developmental toxicity
Description of key information
In an oral developmental toxicity study conducted to OECD 414 and to GLP (Safepharm Laboratories Ltd., 1991) there were no effects on rat foetal development and the NOAEL was therefore at least 1000 mg/kg bw/day (the highest dose tested).
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
In addition to the key developmental study, no adverse effects on the landmarks of offspring development or on the offspring response to simple reflexological tests were observed in a one-generation reproductive toxicity study (Safepharm Laboratories Ltd., 1992).
Justification for classification or non-classification
Based on the available oral reproductive and developmental toxicity studies, triethoxyisobutylsilane is not classified for effects on fertility or development according to Regulation 1272/2008/EC.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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