Registration Dossier
Registration Dossier
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EC number: 402-810-3 | CAS number: 17980-47-1 DYNASILAN BH N; DYNASILAN BSM 100 N; DYNASILAN NH 42
Endpoint summary
Administrative data
Description of key information
In a skin irritating study conducted using a protocol comparable to OECD 404 and to GLP (Huntingdon Research Centre Ltd., 1988a) triethoxyisobutylsilane was mildly irritaing to the skin of rabbits, but this irritation did not meet the criteria for classification.
In an eye irritation study conducted using a protocol comparable to OECD 405 and to GLP (Huntingdon Research Centre Ltd., 1988b) triethoxyisobutylsilane was not irritating to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
There is a reliable study available for each of skin and eye irritation. There were very minor, isolated signs of respiratory tract irritation in the acute and repeated dose toxicity studies, but these do not meet the criteria for classification. However, the substance was previously classified as R38; Skin Irrit. 2 in Annex VI of Regulation 1272/2008/EC, and this is upheld.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
Based on the available skin and eye irritation studies in rabbits, triethoxyisobutylsilane is not classified for skin, eye or respiratory tract irritation according to Regulation 1272/2008/EC. However, the substance was previously classified as R38; Skin Irrit. 2 in Annex VI of Regulation 1272/2008/EC, and this is upheld.
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