Registration Dossier
Registration Dossier
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EC number: 939-719-8 | CAS number: 5502-75-0
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 April 2012 to 26 July 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Purity test date: 29-Feb-12 - Radiolabelling:
- no
- Test temperature:
- No data
- Details on study design: HPLC method:
- - Apparatus: Agilent Technologies 1200 Series, incorporating autosampler
- Column: XSelect HSS Cyano (150 x 4.6 mm id)
- Mobile phase: methanol:reverse osmosis water (55:45 v/v)
- pH of mobile phase: 6.81
- Detection system: Refractive index detector
- Solutes for dissolving test and reference substances: methanol
DETERMINATION OF DEAD TIME:
The dead time was determined by measuring the retention time of formamide (purity* 99.94%, 5930 mg/L solution in methanol:reverse osmosis water 55:45 v/v).
REFERENCE SUBSTANCES
Acetanilide
Phenol
Atrazine
Isoproturon
Triadimenol
Linuron
Naphthalene
Endosulfan-diol
Fenthion
Phenanthrene
Diclofop-methyl
DDT
REPETITIONS
- Number of determinations: duplicate
EVALUATION
- Calculation of capacity factors k': k' = (tr - t0) / t0; k' - capacity factor, tr = retention time (min), t0 - dead time (min)
- Determination of the log Koc value: log Koc = (log k' - A) / B; Koc = adsorption coefficient, k' = capacity factor, A = intercept of the calibration curve, B = Slope of the calibration curve - Key result
- Type:
- log Koc
- Value:
- 2.76
- Key result
- Type:
- Koc
- Value:
- 569
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
Acetanilide 2.866 min
Phenol 2.758 min
Atrazine 3.910 min
Isoproturon 4.223 min
Triadimenol 5.792 min
Linuron 5.998 min
Naphthalene 5.202 min
Endosulfan-diol 7.596 min
Fenthion 9.216 min
Phenanthrene 10.062 min
Diclofop-methyl 14.774 min
DDT 31.885 min
- Details of fitted regression line (log k' vs. log Koc): y = 0.3549x - 0.746
- Graph of regression line attached: yes
- Average retention data for test substance: 5.6485 min - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be 569, log10 Koc 2.76.
- Executive summary:
According to OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)), the adsorption coefficient of the test substance on soil and sewage sludge is estimated as log Koc of 2.76.
Reference
Description of key information
According to OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC)), the adsorption coefficient of the test substance on soil and sewage sludge is estimated as log Koc of 2.76.
Key value for chemical safety assessment
- Koc at 20 °C:
- 569
Additional information
The key study is a Klimisch-1, GLP-compliant study, sponsored by Firmenich SA and carried out in 2012 by Harlan Laboratories Ltd. according to OECD 121 and EU Method C.19 (HPLC estimation method). The adsorption coefficient of the substance in soil and in sewage sludge was estimated by comparison of the substance’s retention time compared to the retention times of 12 reference compounds. The adsorption coefficient of the test substance on soil and sewage sludge is estimated as log Koc of 2.76, corresponding to a Koc value at 569. The result indicates that the substance is low mobile in soils (according to P.J. McCall et al., 19811).
1McCall P.J., Laskowski D.A., Swann R.L., and Dishburger H.J., (1981), “Measurement of sorption coefficients of organic chemicals and their use, in environmental fate analysis”, in Test Protocols for Environmental Fate and Movement of Toxicants. Proceedings of AOAC Symposium, AOAC,
Washington DC.
Mobility classification scheme:
Range of Koc |
Mobility class |
0 - 50 |
Very high |
50 - 150 |
High |
150 - 500 |
Medium |
500 - 2000 |
Low |
2000 - 5000 |
Slightly |
> 5000 |
Immobile |
[LogKoc: 2.76]
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