Registration Dossier
Registration Dossier
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EC number: 443-870-0 | CAS number: 163520-33-0
Endpoint summary
Administrative data
Description of key information
Additional information
The toxicity of the test item was investigated in GLP studies with aquatic organisms of different trophic levels (invertebrates, fish, algae and aquatic plants). Due to the hydrolysis of the substance with a DT50 of 2.3 d, the available tests on fish and aquatic invertebrates were performed in flow-through test systems.
Acute toxicity tests (96 h) according to OECD 203 with two freshwater fish species, bluegill sunfish (Lepomis macrochirus) and rainbow trout (Oncorhynchus mykiss), resulted in LC50-values ranging from 0.22 mg/L to 0.34 mg/L (based on analytically verified test concentrations in flow-through systems). An acute toxicity test on freshwater invertebrates (Daphnia magna) (OECD 202) revealed no toxic effect observable at 0.51 mg/L, the maximum solubility of the test substance. Thus, the EC50 (48 h) value for invertebrates is greater than 0.51 mg/L (based on analytically verified test concentrations in flow-through systems).
For freshwater algae (Pseudokirchneriella subcapitata), no toxic effects occurred up to the maximum solubility of the test item in a test following OECD 201. Hence, the EC50 (72 h) value for aquatic algae is greater than 1.26 mg/L. However, it must be taken into account that the test substance fully hydrolysed over the time span of the study since the test was carried out under static conditions.
As an example for higher aquatic plants, duckweed (Lemna gibba) was exposed to the test substance at its maximum solubility of the substance in the test medium in a semi-static test system according to EPA OPP 123 -2. The medium renewal rate was 2 days. No toxic effects were observed under these conditions over a period of 7 days.
A long-term study according to OECD 210 is proposed to assess the long-term effects for chronic toxicity on fish, the most sensitive organism when comparing the available short-term toxicity data.
Additionally, the effect of the test substance on microorganisms (activated sludge) was examined. In this test system, only a moderate inhibitory effect of 12.7% on microbial respiration was observed at a nominal concentration of 1000 mg/L which represents the highest concentration tested.
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