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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
500 mg Pigment Yellow FC 26290 were semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Evaluation of skin irritation was made until day 7 according to Draize
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Pigment Yellow FC 26290; BALK-No.; 92/026-N

Test animals

Species:
rabbit
Strain:
other: HC:NZW

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: shorn
Vehicle:
water
Controls:
not required
Duration of treatment / exposure:
4 hours
Observation period:
7 days
Number of animals:
3 female rabbits

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 1 h, 24 h, 48 h, 72 h, 7 d
Score:
0
Max. score:
8
Reversibility:
other: score = 0 at any time point
Other effects:
no other effects found

Any other information on results incl. tables

The results of the exposure of the test substance to the skin did not show any signs of irritation in all 3 animals

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Executive summary:

500 mg Pigment Yellow FC 26290 were semiocclusively applied once to the intact skin of 3 female adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Evaluation of skin irritation was made until day 7 according to Draize.

The test substance was not irritating to the skin (score = 0 at any time point).