Ethyl formate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

data is from experimental reports

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To assess the dermal irritation potential of the test chemical in rabbits

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl formate

EC Number:

203-721-0

EC Name:

Ethyl formate

Cas Number:

109-94-4

Molecular formula:

C3H6O2

IUPAC Name:

ethyl formate

Test material form:

liquid

Details on test material:

- Name of test material (IUPAC Name): Ethyl formate
- Molecular formula: C3H6O2
- Molecular weight: 74.0784 g/mol
- Smiles notation: O(CC)C=O
- InChI: 1S/C3H6O2/c1-2-5-3-4/h3H,2H2,1H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

rabbit

Strain:

not specified

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

undiluted

Duration of treatment / exposure:

single

Observation period:

24 hours till 8 days

Number of animals:

no data available

Details on study design:

TEST SITE
- Area of exposure: backs and ears

OBSERVATION TIME POINTS
(indicate if minutes, hours or days) : 24 hours till 8 days

SCORING SYSTEM:
Sign explanation for skin and mucous membrane irritation:
R - redness; oe= Edema; Sch = Scaling ; N = necrosis; Tr = Cloudiness; Na = scar; (+) = questionable; + = easy; ++ = strong; +++ = very strong; * = unimpressive

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24 h

Reversibility:

fully reversible within: 8 days

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

On the skin, ethyl formate triggers slight and reversible primary irritation only with prolonged exposure.

Any other information on results incl. tables

Skin Irritation (Rabbits)

Application Form: undiluted

Exposure time	Findings after 24 hours	Findings after 8 days
Back, 1’	*	*
5’	*	*
15’	*	*
Back, 20’	*	*
Ear, 20’	R+	*

Sign explanation for skin and mucous membrane irritation:

R - redness; oe= Edema; Sch = Scaling ; N = necrosis; Tr = Cloudiness; Na = scar; (+) = questionable; + = easy; ++ = strong; +++ = very strong; * = unimpressive

Applicant's summary and conclusion

Interpretation of results:

other: not irritating

Conclusions:

On the skin, the test chemical triggers slight and reversible primary irritation only with prolonged exposure.
Hence, the test chemical was considered to be not irritating to skin.

Executive summary:

The dermal irritation potential of the test chemical was assessed in rabbits. Undiluted ethyl formate was applied to the skin of the ears and back of the rabbits and observed for erythema and edema. The dermal responses were observed and scored from 24 hours after exposure till 8 days.

On the skin, the test chemical triggers slight and reversible primary irritation only with prolonged exposure.

Hence, test chemical was considered to be not irritating to skin.