Ethyl formate

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD Guideline.

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Principles of method if other than guideline:

The partition Coefficient n-octanol/water of chemical Ethyl formate was determined by the Reverse Phase High Performance Liquid Chromatography method according to OECD Guideline No. 117 for testing of Chemicals.

GLP compliance:

no

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

1.504

Temp.:

25 °C

pH:

4.61

Remarks on result:

other: Log Pow value reported as 1.504±0.003

Details on results:

The Partition coefficient (Pow) of the Ethyl formate was determined to be 1.504±0.003 at 25°C

Reference substance	Log Pow	tR1	tR2	tR3	MeantR± S.D.	k	Log k
Formamide	-	0.977	0.922	0.922	0.940±0.032	-	-
Acetanilide	1	1.081	1.082	-	1.081±0.001	0.1501	-0.823
2 nitro phenol	1.8	1.366	1.369	-	1.367±0.002	0.4543	-0.342
Benzene	2.1	1.771	1.775	-	1.773±0.003	0.886	-0.171
Naphthalene	3.6	2.388	2.393	-	2.390±0.004	1.5422	0.421
Biphenyl	4	2.822	2.841	-	2.831±0.013	2.011	0.629
n butyl benzene	4.6	4.454	4.463	-	4.458±0.006	3.741	0.572

Table 1: Results of test substance

Test substance		K	Log k	Log Pow by Generalized Calibration Graph	Mean of Log Pow± S.D.
tR1	1.223	0.301	-0.521	1.502	1.504± 0.003
tR2	1.224	0.302	-0.520	1.506

Conclusions:

The partition coefficient(n-octanol/water) of test substance Ethyl formate was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 1.504±0.003 at 25°C

Executive summary:

The partition Coefficient n-octanol/water of chemical Ethyl formate (CAS no. 109 -94 -4) was determined by the Reverse Phase High Performance Liquid Chromatography method according to OECD Guideline No. 117 for testing of Chemicals. A test item solution was prepared by accurately weighing 50mg of test item and diluted with mobile phase up to 100ml. Thus, the test solution concentration was 500mg/l. The pH of test substance was 4.61.The reference substances were chosen according to structural similarity with the test substance. The reference substances wereAcetanilide, 2 nitro phenol,Benzene, Naphthalene,Biphenyl, andn butyl benzenehaving Pow value ranging from 1 to 4.6.The Log Pow value of the test chemical Ethyl formate was determined to be 1.504±0.003 at 25°C. On the basis of this value, the test substance Ethyl formate can be considered to be hydrophilic in nature.

Description of key information

Based on the available data from study report,the partition Coefficient n-octanol/water of chemical Ethyl formate (CAS no. 109 -94 -4) was determined by the Reverse Phase High Performance Liquid Chromatography method according to OECD Guideline No. 117 for testing of Chemicals. A test item solution was prepared by accurately weighing 50mg of test item and diluted with mobile phase up to 100ml. Thus, the test solution concentration was 500mg/l. The pH of test substance was 4.61.The reference substances were chosen according to structural similarity with the test substance. The reference substances wereAcetanilide, 2 nitro phenol,Benzene, Naphthalene,Biphenyl, andn butyl benzenehaving Pow value ranging from 1 to 4.6.The Log Pow value of the test chemical Ethyl formate was determined to be 1.504±0.003 at 25°C. On the basis of this value, the test substance Ethyl formate can be considered to be hydrophilic in nature.

Key value for chemical safety assessment

Log Kow (Log Pow):

1.504

at the temperature of:

25 °C

Additional information

Based on the available data in a key study from study report,the partition Coefficient n-octanol/water of chemical Ethyl formate (CAS no. 109 -94 -4) was determined by the Reverse Phase High Performance Liquid Chromatography method according to OECD Guideline No. 117 for testing of Chemicals. A test item solution was prepared by accurately weighing 50mg of test item and diluted with mobile phase up to 100ml. Thus, the test solution concentration was 500mg/l. The pH of test substance was 4.61.The reference substances were chosen according to structural similarity with the test substance. The reference substances were Acetanilide, 2 nitro phenol, Benzene, Naphthalene, Biphenyl, and n-butyl benzene having Pow value ranging from 1 to 4.6.The Log Pow value of the test chemical Ethyl formate was determined to be 1.504±0.003 at 25°C.

In a supportingstudy from handbook, peer reviewed journal, authoritative and modelling databases, the partition coefficient (log Pow) value of the substance Ethyl formate was determined to be 0.23.

Additional study from authoritative database and peer reviewed journalindicates that the octanol water partition coefficient (log Pow) value of the substance Ethyl formate was determined to be 0.27.

In an another supporting study from handbooks, the partition coefficient (log Pow) value of the substance Ethyl formate was determined to be 0.33.

Thus, based on the available information, the logPow valueof the test substance Ethyl formate ranges from 0.23 to 1.504, respectively. On the basis of this experimental value, chemical Ethyl formate can be considered to be hydrophilic in nature.